2012 Fiscal Year Final Research Report
Demonstration of the formation of cyclobutane pyrimidine dimers through the excited triplet state mediated by solar UV radiation
| Project/Area Number |
23651044
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Risk sciences of radiation/Chemicals
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOMURA Junichiro 東北大学, 大学院・医学系研究科, 助教 (10215410)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 紫外線 / 光生物学 / 光化学 / 環境 |
|---|
| Research Abstract |
I tried to demonstrate that the formation of cyclobutane pyrimidine dimers (CPDs) by long wavelength UV radiations is mediated by a photochemical reaction through the excited triplet states of DNA bases. However, it was reported by others that the long wavelength UV-induced CPD formation is mediated by another novel mechanism, which made us change the goal of this research and characterize the novel mechanism by studying comparatively the mutation spectra induced by long wavelength UV. We found that solar-UV signature mutations, which we had identified before as solar UV-specific mutations, are caused through the CPDs produced by this novel mechanism, and are induced most efficiently by UVA1.
|
