2011 Fiscal Year Final Research Report
Development of a method for the mechanistic investigation of toxicological endpoints modulated by microRNAs
| Project/Area Number |
23651052
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YOSHIOKA Wataru 東京大学, 大学院・医学系研究科, 特任助教 (80425496)
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| Project Period (FY) |
2011
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| Keywords | 毒性発現メカニズム |
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| Research Abstract |
MicroRNA(miRNA) is a class of small RNA that functions as a negative regulator of gene expression. Human and mouse genomes encode over 1, 400 and 700 miRNAs, respectively. Most of the cellular pathways are considered to be modulated by miRNAs, and some miRNAs have been implicated to be involved in the onset of toxic effects of chemicals. In the present study, we developed a method to increase the function of targeted miRNAs ; administration of miRNAs could increase the abundance of their functional form.
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