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2012 Fiscal Year Final Research Report

Development of micro blood-brain barrier

Research Project

  • PDF
Project/Area Number 23651134
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Microdevices/Nanodevices
Research InstitutionGunma University

Principal Investigator

SATO Kiichi  群馬大学, 大学院・工学研究科, 准教授 (50321906)

Project Period (FY) 2011 – 2012
Keywordsマイクロチップ / 血液脳関門 / 動物実験代替法
Research Abstract

PDMS microchip with a porous membrane for cell culture support was developed as a micro model of the blood-brain barrier. Vascular endothelial cell line from monkey and human fibroblast-like cell line were co-cultured on both sides of the membrane. Permeability tests of fluorescent molecules were conducted with the microfluidic device. I confirmed the cell sheet in the device acted as a permeability barrier.

  • Research Products

    (6 results)

All 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] Microcirculation System with a Dialysis Part for Bioassays Evaluating Anticancer Activity and Retention2013

    • Author(s)
      Yuki IMURA, Etsuro YOSHIMURA, Kiichi SATO
    • Journal Title

      Analytical Chemistry

      Volume: 85 Pages: 1683-1688

    • DOI

      DOI:10.1021/ac302938q

    • Peer Reviewed
  • [Journal Article] Micro Total Bioassay System for Oral Drugs: Evaluation of Gastrointestinal Degradation, Intestinal Absorption, Hepatic Metabolism, and Bioactivity2012

    • Author(s)
      Yuki IMURA, Etsuro YOSHIMURA, Kiichi SATO
    • Journal Title

      Analytical Sciences

      Volume: 28 Pages: 197-199

    • DOI

      DOI:10.2116/analsci.28.197

    • Peer Reviewed
  • [Presentation] Simultaneous measurement of dialysate and sample solution in a microdialysis system2012

    • Author(s)
      Yu Sakuta, Kin-ichi TSUNODA, Kiichi SATO
    • Organizer
      RSC Tokyo International Conference
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2012-09-06
  • [Presentation] 空気圧駆動ポンプを組み込んだマイクロ透析システムの開発2012

    • Author(s)
      作田悠、角田欣一、佐藤記一
    • Organizer
      第25回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      崇城大学(熊本市)
    • Year and Date
      2012-05-18
  • [Presentation] マイクロチップを用いたバイオアベイラビリティ評価法の開発2011

    • Author(s)
      佐藤記一
    • Organizer
      第25回動物細胞工学シンポジウム
    • Place of Presentation
      キャンパス・イノベーションセンター国際会議室(東京)(招待講演)
    • Year and Date
      2011-05-30
  • [Presentation] Development of a Micro Cardiovascular System for Bioassay of Anticancer Activity and Renal Clearance2011

    • Author(s)
      Kiichi SATO, Yuki IMURA, Etsro YOSHIMURA
    • Organizer
      IUPAC International Congress on Analytical Sciences 2011 (ICAS2011)
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2011-05-25

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Published: 2014-09-25  

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