2012 Fiscal Year Final Research Report
Development of micro blood-brain barrier
| Project/Area Number |
23651134
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Microdevices/Nanodevices
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| Research Institution | Gunma University |
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Principal Investigator |
SATO Kiichi 群馬大学, 大学院・工学研究科, 准教授 (50321906)
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| Project Period (FY) |
2011 – 2012
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| Keywords | マイクロチップ / 血液脳関門 / 動物実験代替法 |
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| Research Abstract |
PDMS microchip with a porous membrane for cell culture support was developed as a micro model of the blood-brain barrier. Vascular endothelial cell line from monkey and human fibroblast-like cell line were co-cultured on both sides of the membrane. Permeability tests of fluorescent molecules were conducted with the microfluidic device. I confirmed the cell sheet in the device acted as a permeability barrier.
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