2012 Fiscal Year Final Research Report
Construction of enzyme modelsreducing carbon dioxide
| Project/Area Number |
23655049
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Inorganic chemistry
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 生物無機化学 / 酵素モデル / 水素結合 / タングステン / モリブデン |
|---|
| Research Abstract |
Formate dehydrogenase, which reduces carbon dioxide, is one of tungsto- and molybdoenzymes. These enzymes contain unique dithiolene moieties called molybdopterin cofactor. In this work, toluene-soluble model complexes having super-bulky substituents and NH・・・S hydrogen bonds weresynthesized. The active molybdenum site was stabilized by hydrophobic surroundings even in aqueous micellar solution. The model complex successfully reduced substrates which are hardly reducible by known models.
|
Research Products
(17 results)
