2013 Fiscal Year Final Research Report
reconstruction of an external stimulus-dependent replication system
| Project/Area Number |
23655164
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Chemistry related to living body
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
WATANABE Satoru 独立行政法人理化学研究所, 独立行政法人理化学研究所・生命システム研究センター, 上級研究員 (80300945)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 複製 / 合成生物学 / DNA / 抗体 |
|---|
| Research Abstract |
Human has a natural gift to select appropriate antibody molecules from huge variety of molecular library, while an engineering technique that reconstructs the selection process against an antigen of interest in a test tube is immature because the variety of the library molecules is a critical and limiting factor of the current technique. I propose a new and challenging idea that breaks the limitation by looking each DNA molecule as a test tube. The feasibility of the idea was experimentally studied and some elementary steps of the idea were shown to be realized.
|
