Cancer cell selective magnetic nanoaprticles and application for hyperthermia treatment

2013 Fiscal Year Final Research Report

• Project/Area Number: 23656013
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied materials science/Crystal engineering
• Research Institution: Yokohama National University
• Principal Investigator: ICHIYANAGI Yuko 横浜国立大学, 工学研究院, 准教授 (90240762)
• Project Period (FY): 2011 – 2013
• Keywords: magnetic hypertnermia / nanoparticle / ac susceptibility / cancer / ferrites / relaxation loss

Research Abstract

Magnetic nanoparticles encapsulated in amorphous SiO2 were prepared using our original wet chemical method. The cancer cell selective magnetic particles were developed by functionalization. Magnetization measurements were performed for various composition and particle size. AC magnetic susceptibility measurements were performed for samples, and particle composition, size were optimized for magnetic hyperthermia treatment.
In vitro experiments to study the hyperthermia effects on cancerous cells were carried out and drastic effects were obtained.

Research Products

• [Journal Article] Magnetic and Dielectric Properties of Multiferroic Bi1-xGdxFeO3 (2014)
  • Author(s): T . Y ANOH, A. KUROKA W A, T . MIY ASAKA, K. MORI, M. HACHISU, H. T AKEUCHI, S. Y ANO, K. ONUMA, T . KONDO, K. MIIKE and Y . ICHIYANAGI
  • Journal Title: Journal of the Japan Society of Powder and Powder Metallurgy Volume: Vol.61No.S1 Pages: S30-S33
  • Peer Reviewed
• [Journal Article] Superparamagnetic behavior of Fe-doped SnO2 nanoparticles (2014)
  • Author(s): M. Hachisu, K. Onuma, T . Kondo, K. Miike, T . Miyasaka, K. Mori, and Y . Ichiyanagi
  • Journal Title: AIP Conf. Proc Volume: 1585 Pages: 3
  • Peer Reviewed
• [Journal Article] Preparation and magnetic properties of multiferroic CuMnO2 nanoparticles (2014)
  • Author(s): Akinobu Kurokawa, T akuya Y anoh, Shinya Y ano, and Y uko Ichiyanagi
  • Journal Title: Journal of Nanoscience and Nanotechnology Volume: 14,(3) Pages: 2553-2556
  • Peer Reviewed
• [Journal Article] Magnetic Properties of MgFe 2O4 Nanoparticles and Zn Doping Effect (2013)
  • Author(s): T . Kondo, A. Kurokawa, H. T akeuchi, T . Y anoh, S. Y ano, K. Onuma, K. Miike, T . Miyasaka and Y . Ichiyanagi
  • Journal Title: Trans. Mat. Res. Soc. Japan Volume: 38[4] Pages: 513-516
  • Peer Reviewed
• [Journal Article] Development of functional magnetic nanoparticles for biomedical application (2013)
  • Author(s): Yuko Ichiyanagi
  • Journal Title: Proceedings of SPIE, Oxide-based Materials and Devices III Volume: Vol.8263 Pages: 191-197
  • Peer Reviewed
• [Journal Article] 月刊バイオインダストリー 特集 : ナノメディシン最前線 (2013)
  • Author(s): 一柳優子
  • Journal Title: 「がん細胞選択性機能を持つ磁気ナノ微粒子の開発とハイパーサーミアへの応用」シーエムシー出版 Volume: 6月号 Pages: 33-39
  • Peer Reviewed
• [Journal Article] Production of Fe_3-xZn_xO_4 nanoparticles for agents in hyperthermia treatment (2013)
  • Author(s): H. T akeuchi, A. Kurokawa, T . Y anoh, S. Y ano, K. Onuma, T . Kondo, K. Miike, T . Miyasaka, M. Hachisu, K. Mori and Y . Ichiyanagi
  • Journal Title: Journal of Basic and Applied Physics Volume: Vol.2,Iss.4 Pages: 201-204
  • Peer Reviewed
• [Journal Article] Synthesis and study of magnetic properties of Co-doped anatase TiO2 nanoparticles (2013)
  • Author(s): S Y ano, A Kurokawa, H T akeuchi, T Y anoh, K Onuma, T Kondo, K Miike, T Miyasaka and Y Ichiyanagi
  • Journal Title: Journal of Physics : Conference Series Volume: 433 Pages: 012019
  • Peer Reviewed
• [Journal Article] Synthesis of multiferroic DyFeO3 nanoparticles and study of their magnetic properties (2012)
  • Author(s): L Zhu, N Sakai, T Y anoh, S Y ano, N Wada, H T akeuchi, A Kurokawa, and Y Ichiyanagi
  • Journal Title: Journal of Physics : Conference Series Volume: 352 Pages: 012021
  • Peer Reviewed
• [Journal Article] Analysis of Complex Materials using Functionalized Magnetic Nanoparticles (2012)
  • Author(s): Shu Taira, Yuko Ichiyanagi
  • Journal Title: "Magnetic Nanoparticles : Properties, Synthesis and Applications" Chapter 5, Nova Publishers Pages: 179-204
  • Peer Reviewed
• [Journal Article] Magnetic Properties and X-ray Absorption Fine-Structure Spectra of CoMn2O4 Nanoparticles (2012)
  • Author(s): Toshiki Miyasaka, Akinobu Kurokawa, Hiromasa T akeuchi, Shinya Yano, TakuyaY anoh, Kazuki Onuma, T akaya Kondo, Kazunari Miike, and Yuko Ichiyanagi
  • Journal Title: e-J. Surf. Sci. Nanotech Volume: Vol.10 Pages: 643-646
  • Peer Reviewed
• [Journal Article] Synthesis of Gd2O3 nanoparticles for MRI contrast agents (2012)
  • Author(s): N Sakai, L Zhu, A Kurokawa, H Takeuchi, S Yano, T Yanoh, N Wada, S. T aira, Y Hosokai, A Usui, Y Machida, H Saito and Y Ichiyanagi
  • Journal Title: Journal of Physics : Conference Series Volume: 352 Pages: 012008
  • Peer Reviewed
• [Journal Article] Effect of Heat Treatment on Jahn-Teller Distortion and Magnetization in Cu Ferrite Nanoparticles (2012)
  • Author(s): Shinji Kimura, T oshiyuki Mashino, T omoyuki Hiroki, Daiki Shigeoka, Naoki Sakai, Liming Zhu, Y uko Ichiyanagi
  • Journal Title: Thermochimica Acta Volume: 532 Pages: 119-122
  • Peer Reviewed
• [Journal Article] Study on Increase in Temperature of Co-Ti Ferrite Nanoparticles for Magnetic Hyperthermia Treatment (2012)
  • Author(s): Y . Ichiyanagi, D. Shigeoka, T . Hiroki, T . Mashino, S. Kimura, A. Tomitaka, K. Ueda and Y . Takemura
  • Journal Title: Thermochimica Acta Volume: 532 Pages: 123-128
  • Peer Reviewed
• [Presentation] Mn 酸化物ナノ微粒子の XAFS による局所構造解析と磁気特性 (2014)
  • Author(s): 宮坂俊樹, 小沼一紀, 近藤貴哉, 三池和成, 蜂巣将也, 森一将, 菊池祐, 兵藤公美典, 森本翔大, 山崎敦史, 一柳優子
  • Organizer: 物理学会第69回年会
  • Place of Presentation: 平塚
  • Year and Date: 2014-03-27
• [Presentation] Mn 及び Co 系フェライトナノ微粒子の MRI 造影効果と発熱特性 (2014)
  • Author(s): 三池和成, 近藤貴哉, 宮坂俊樹, 小沼一紀, 森一将, 蜂巣将也, 菊池祐, 兵藤公典, 森本翔太, 山崎敦史, 細貝良行, 臼井章仁, 町田好男, 齋藤春夫, 一柳優子
  • Organizer: 物理学会第69回年会
  • Place of Presentation: 平塚
  • Year and Date: 2014-03-27
• [Presentation] 磁気ハイパーサーミアに向けた Mn-Zn ferrite ナノ微粒子の磁気特性及び発熱評価 (2013)
  • Author(s): 近藤貴哉, 小沼一紀, 三池和成, 宮坂俊樹, 蜂巣将也, 森一将, 一柳優子
  • Organizer: 日本物理学会2013年秋季大会, 日本物理学会第68回年次大会
  • Place of Presentation: 徳島
  • Year and Date: 20130925-28
• [Presentation] スピネル型 MMn_2O_4(M =Fe, Ni, Co, Zn)ナノ微粒子の結晶構造変化と磁気特性 (2013)
  • Author(s): 宮坂俊樹, 近藤貴哉, 三池和成, 蜂巣将也, 森一将, 一柳優子
  • Organizer: 日本物理学会2013年秋季大会
  • Place of Presentation: 徳島
  • Year and Date: 20130925-28
• [Presentation] Transition Metal Doping Effects on Electronic States and Magnetic Properties of NiO Nanoparticles (2013)
  • Author(s): A. Kurokawa, S. Y ano, T . Yanoh, M. Hachisu, H. Takeuchi, K. Onuma, T . Kondo, K. Miike, T . Miyasaka, K. Mori, S. Kaido, Y . Ichiyanagi
  • Organizer: Intl.Conf. Fine Particle Magnetism
  • Place of Presentation: Perpignan フランス
  • Year and Date: 20130624-27
• [Presentation] Production of Fe 3-xZnx O4 Nanoparticles for Agents in Hyperthermia Treatment (2013)
  • Author(s): H. Takeuchi, A. Kurokawa, T . Yanoh, S. Yano and Y . Ichiyanagi
  • Organizer: Intl.Conf. Fine Particle Magnetism
  • Place of Presentation: Perpignan フランス
  • Year and Date: 20130624-27
• [Presentation] Core-shell 型 Co フェライトの MRI 造影効果におけるシリカ層の影響 (2013)
  • Author(s): 三池和成, 近藤貴哉, 宮坂俊樹, 森 一将, 蜂巣将也, 細貝良行, 臼井章仁, 町田好男, 齋藤春夫, 一柳優子
  • Organizer: ナノ学会第11回大会
  • Place of Presentation: 東工大・100年記念館
  • Year and Date: 20130606-08
• [Presentation] スピネル型 Mn 酸化物ナノ微粒子の SiO2 包含効果と局所構造解析 (2013)
  • Author(s): 宮坂俊樹, 近藤貴哉, 三池和成, 蜂巣将也, 森 一将, 一柳優子
  • Organizer: ナノ学会第11回大会
  • Place of Presentation: 東工大・100年記念館
  • Year and Date: 20130606-08
• [Presentation] 磁気ハイパーサーミアに向けたフェライトナノ微粒子の磁気特性と発熱特性 (2013)
  • Author(s): 近藤貴哉, 竹内宏賢, 三池和成, 宮坂俊樹, 蜂巣正也, 森 一将, 一柳優子
  • Organizer: ナノ学会第11回大会
  • Place of Presentation: 東工大・100年記念館
  • Year and Date: 20130606-08
• [Presentation] Fe3-xCoxO4(x = 0.3, 0.5)ナノ微粒子の磁気特性及び磁気ハイパーサーミアに向けた発熱評価 (2013)
  • Author(s): 竹内宏賢, 黒川瑛宣, 矢納拓弥, 矢野真也, 小沼一紀, 近藤貴哉, 三池和成, 宮坂俊樹, 海藤翔太, 蜂巣将也, 森一将, 一柳優子
  • Place of Presentation: 大阪
  • Year and Date: 20130326-29
• [Presentation] Self-heating properties and MRI contrast of multifunctional magnetic nanoparticles (2013)
  • Author(s): Yuko Ichiyanagi
  • Organizer: EMN Fall meeting Orlando
  • Place of Presentation: USA
  • Year and Date: 2013-12-09
  • Invited
• [Presentation] Structural Characteristics and Ionization Ability of Manganese Oxide Nanoparticles (2013)
  • Author(s): Kazuki Onuma, Tomoyuki Hiroki, Yuko Ichiyanagi
  • Organizer: 9th International Symposium on Atomic Level Characterizations for New Materials and Devices '13 (ALC'13)
  • Place of Presentation: Kona, USA
  • Year and Date: 2013-12-05
• [Presentation] Local Structure Control of Manganese Oxide Nanoparticles Encapsulated by Amorphous SiO2 (2013)
  • Author(s): Toshiki Miyasaka, Takaya Kondo, Kazunari Miike, Kazuki Onuma, Masaya Hachisu, Kazumasa Mori, and Yuko Ichiyanagi
  • Organizer: 9th International Symposium on Atomic Level Characterizations for New Materials and Devices '13 (ALC'13)
  • Place of Presentation: Kona
  • Year and Date: 2013-12-05
• [Presentation] Magnetic and self heating properties of Mn-Zn ferrite nanoparticles as agents of hyperthermia treatment (2013)
  • Author(s): T . Kondo, K. Onuma, K. Miike, T . Miyasaka, M. Hachisu, K. Mori, Y . Ichiyanagi
  • Organizer: 7th International Symposium on Nanomedicine
  • Year and Date: 2013-11-08
• [Presentation] Magnetic Properties and MRI Contrast Effect on CoxFe3-xO4 Nanoparticles (2013)
  • Author(s): K. Miike, N. Sakai, Y . Ichiyanagi, Y . Hosokai, A. Usui, Y . Machida, H. Saito
  • Organizer: 7th International Symposium on Nanomedicine Kitakyushu
  • Place of Presentation: Best Poster Award
  • Year and Date: 2013-11-08
• [Presentation] Synthesis of the PEI coated cobalt ferrite nanoparticles for magnetic hyperthermia (2013)
  • Author(s): K. Mori, K. Onuma, T . Kondo, K. Miike, T . Miyasaka, M. Hachisu, Y . Kikuchi, Y .Ichiyanagi
  • Organizer: 7th International Symposium on Nanomedicine Kitakyushu
  • Year and Date: 2013-11-08
• [Presentation] Optimization of Self-Heating Properties of Multifunctional Magnetic Nanoparticles (2013)
  • Author(s): Yuko Ichiyanagi
  • Organizer: 7th International Symposium on Nanomedicine Kitakyushu
  • Year and Date: 2013-11-07
  • Invited
• [Presentation] SELF HEA TING PROPERTIES OF Mn-Zn FERRITE NANOP ARTICLES AS AGENTS FOR HYPERTHERMIA TREA TMENT (2013)
  • Author(s): Takaya KONDO, Kazumasa MORI, Kazunari MIIKE, Toshiki MIY ASAKA, Kazuki ONUMA, Masaya HACHISU and Yuko ICHIYANAGI
  • Organizer: The Fifth International Symposium on the New Frontiers of Thermal Studies of Materials
  • Place of Presentation: Yokohama
  • Year and Date: 2013-10-28
• [Presentation] TG-DT A ANAL YSIS OF PEI COA TED COBAL T FERRITE NANOP ARTICLES FOR MAGNETIC HYPERTHERMIA (2013)
  • Author(s): Kazumasa MORI, Yu KIKUCHI, Takaya KONDO, Kazunari MIIKE, Kazuki ONUMA, T oshiki MIY ASAKA, Masaya HACHISU and Yuko ICHIYANAGI
  • Organizer: The Fifth International Symposium on the New Frontiers of Thermal Studies of Materials
  • Place of Presentation: Yokohama
  • Year and Date: 2013-10-28
• [Presentation] Functional Magnetic Nanoparticles for Hyperthermia Treatment and MRI Agent (2013)
  • Author(s): Y . Ichiyanagi, H. Takeuchi, T . Kondo, K. Miike, T . Miyasaka, K. Onuma, M. Hachisu, and K. Mori
  • Organizer: Seeheim SCM2013
  • Place of Presentation: Frankfurt. Germany
  • Year and Date: 2013-10-03
  • Invited
• [Presentation] Functional magnetic nanoparticles and biomedical applications (2013)
  • Author(s): Yuko Ichiyanagi
  • Organizer: EMN WEST MEETING
  • Place of Presentation: Houston USA
  • Year and Date: 2013-01-09
  • Invited
• [Presentation] 金属酸化物ナノ微粒子の磁気特性と MRI 造影効果 (2012)
  • Author(s): 三池和成, 細貝良行, 臼井章仁, 町田好男, 斉藤春夫, 一柳優子
  • Organizer: 日本物理学会秋季大会
  • Place of Presentation: 横浜
  • Year and Date: 20120919-22
• [Presentation] Mn-Zn ferrite ナノ微粒子の作製と磁気特性及び発熱特性 (2012)
  • Author(s): 近藤貴哉, 黒川瑛宣, 矢納拓弥, 竹内宏賢, 矢野真也, 小沼一紀, 宮坂俊樹, 三池和成, 一柳優子
  • Organizer: 日本物理学会秋季大会
  • Place of Presentation: 横浜
  • Year and Date: 20120919-22
• [Presentation] Evaluation and application of magnetic nanoparticles (2012)
  • Author(s): Yuko Ichiyanagi
  • Organizer: XAFS15 Satellite workshop, XAFS theory and nano particles
  • Place of Presentation: Chiba, Japan
  • Year and Date: 20120718-20
• [Presentation] Magnetic properties and XAFS spectra of CoMn_2O_4 Nanoparticles (2012)
  • Author(s): T . Miyasaka, A. Kurokawa, H. T akeuchi, S. Y ano, T . Y anoh, K. Onuma, T . Kondo, K. Miike and Y . Ichiyanagi
  • Organizer: XAFS15 Satellite workshop, XAFS theory and nano particles
  • Place of Presentation: Chiba, Japan
  • Year and Date: 20120718-20
• [Presentation] Synthesis and Magnetic Properties of Fe-doped NiO Nanoparticles (2012)
  • Author(s): A. Kurokawa, N. Sakai, L. Zhu, H. Takeuchi, S. Yano, T . Yanoh, K. Onuma, T . Kondo, K. Miike, T . Miyasaka, Y . Ichiyanagi
  • Organizer: ICM2012
  • Place of Presentation: Busan, Korea
  • Year and Date: 20120708-13
• [Presentation] Production of Fe3-x Znx O4 nanoparticles for agents in hyperthermia treatment (2012)
  • Author(s): H T akeuchi , A Kurokawa , T Yanoh , S Yano and Y Ichiyanagi
  • Organizer: ICM2012
  • Place of Presentation: Busan, Korea
  • Year and Date: 20120708-13
• [Presentation] Functional Magnetic Nanoparticles for Hyperthermic and Imaging Agent (2012)
  • Author(s): Yuko Ichiyanagi
  • Organizer: 5th International Symposium on Nanomedicine (ISNM2011)
  • Place of Presentation: Nagoya University ES Hall
  • Year and Date: 20120315-17
  • Invited
• [Presentation] Multifunctional Magnetic Nanoparticles for Biomedical Applications (2012)
  • Author(s): Yuko Ichiyanagi
  • Organizer: 6th International Symposium on Nanomedicine
  • Place of Presentation: Matsue Japan
  • Year and Date: 2012-11-29
  • Invited
• [Presentation] Magnetic Properties of MgFe_2O_4 Nanoparticles and Zn Doping Effect (2012)
  • Author(s): T . Kondo, H. Takeuchi, A. Kurokawa, T . Yanoh, S. Y ano, K. Miike, T . Miyasaka, K. Onuma, S. Ohrui and Y . Ichiyanagi
  • Organizer: IUMRS-International Conference on Electronic Materials
  • Place of Presentation: Yokohama
  • Year and Date: 2012-09-27
• [Presentation] Functional Magnetic Nanoparticles for Hyperthermia Treatment (2012)
  • Author(s): Yuko Ichiyanagi
  • Organizer: 2012 Northeastern Asian Symposium
  • Place of Presentation: Sendai
  • Year and Date: 2012-09-20
  • Invited
• [Presentation] Functional Magnetic Nanoparticles for Hyperthermia and Imaging Agent (2012)
  • Author(s): Yuko Ichiyanagi
  • Organizer: Villa Conference on Interaction Among Nanostructures
  • Place of Presentation: Orland, Florida, USA
  • Year and Date: 2012-04-18
  • Invited
• [Presentation] Development of functional magnetic nanoparticles for biomedical application, Photonic West, SPIE OPTO (2012)
  • Author(s): Yuko Ichiyanagi
  • Organizer: Oxide-based Materials and Devices III Conferenc
  • Place of Presentation: San Fransisco, USA
  • Year and Date: 2012-01-24
  • Invited
• [Presentation] Functional Magnetic Nanoparticles for Biomedical Applications (2011)
  • Author(s): Yuko Ichiyanagi
  • Organizer: BIT' s 1st Annual Symposium of Drug Delivery Systems
  • Place of Presentation: Shenzhen, China
  • Year and Date: 2011-11-04
• [Presentation] 薬剤輸送を目指した磁性ナノ微粒子の機能化
  • Author(s): 森 一将, 小沼一紀, 近藤貴哉, 三池和成, 宮坂俊樹, 蜂巣将也, 一柳優子
  • Organizer: ナノ学会第11回大会
  • Place of Presentation: 東工大・100年記念館
  • Year and Date: 00000606-08
• [Book] Analysis of Complex Materials using Functional Magnetic Nanoparticles, "Magnetic Nanoparticles: Properties, Synthesis and Applications", Chapter 5 (2012)
  • Author(s): S. Taira, Y . Ichiyanagi
  • Total Pages: 322
  • Publisher: Nova Publishers
• [Remarks]
  • URL: http://yukolab.ynu.ac.jp/
• [Patent(Industrial Property Rights)] 温熱療法用 Ni-Zn 系フェライト磁気ナノ微粒子, 及びそれを用いた温熱療法用いた温熱療法用薬物結合複合体 (2012)
  • Inventor(s): 一柳優子, 竹内宏賢, 大類翔太
  • Industrial Property Rights Holder: 一柳優子, 竹内宏賢, 大類翔太
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2012-133436
  • Filing Date: 2012-05-13