2012 Fiscal Year Final Research Report
Identification and functional analysis of chondroitin proteoglycans involved in early cell division of the nematode C. elegans
| Project/Area Number |
23657093
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
NOMURA Kazuya 九州大学, 大学院・理学研究院, 准教授 (30150395)
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| Project Period (FY) |
2011 – 2012
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| Keywords | コンドロイチン / 減数分裂 / 体細胞分裂 / プロテオグリカン / 線虫 / モデル生物 / GPI アンカー |
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| Research Abstract |
Our discovery of involvement of chondroitin proteoglycans in early cell division of the nematode Caenorhabditis elegans (Nature 2003) opened up a new chapter in glycobiology, but the molecular mechanism of their involvement in cell cycle progression remains unknown. In this study, I tried to identify novel chondroitin-core proteins, and found that the chondroitin proteoglycans are involved in meiosis as well as in mitosis of the nematode. The identification of the novel gene network sheds new light on the roles of proteoglycans in cell cycle control.
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[Journal Article] GPI-anchor synthesis is indispensable for the germline development of the nematode2012
Author(s)
Daisuke Murata, Kazuko H. Nomura, Katsufumi Dejima, Souhei Mizuguchi, Nana Kawasaki, Yukari Nakajima, Satsuki Ito, Keiko Gengyo-Ando, Eriko, Kage-Nakadai, Shohei Mitani, Kazuya Nomura
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Journal Title
Caenorhabditis elegansMolecular Biology of the Cell
Volume: Vol. 23(6)
Pages: 982-995
DOI
Peer Reviewed
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