2012 Fiscal Year Final Research Report
Analyses of intracellular signals using a novel activation method for small GTPases
| Project/Area Number |
23657095
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 細胞情報伝達機構 / G蛋白質 |
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| Research Abstract |
Small GTPases play pivotal roles in diverse intracellular signal transduction pathways. In this study, we applied RIRAG method to several small GTPases and found novel signaling pathway that ERK activation was induced by CDC42. The RIRAG method, in the case of CDC42-ERK pathway, was able to dissect the signaling by minute-order. The method potentially becomes a novel tool for the analysis of small GTPase-mediated signaling pathways, although RIRAG method has difficulties in controlling some small GTPases.
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[Journal Article] Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL112011
Author(s)
Sasaki M, Kawahara K, Nishio M, Mimori K, Kogo R, Hamada K, Itoh B, Wang J, Komatsu Y, Yang YR, Hikasa H, Horie Y, Yamashita T, Kamijo T, Zhang Y, Zhu Y, Prives C, Nakano T, Mak TW, Sasaki T, Maehama T, Mori M, Suzuki A
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Journal Title
Nat Med
Volume: 17(8)
Pages: 944-51
DOI
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