2012 Fiscal Year Final Research Report
Regulatory mechanisms of brain function by alternative splicing products of fosB gene
| Project/Area Number |
23657116
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 転写 / 選択的スプライシング / 成体脳神経新生 / てんかん / うつ |
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| Research Abstract |
Under various brain stress, expression of fosB gene which encodes subunits of AP-1 transcription factor is highly induced in the hippocampus of mouse brain. The fosB gene produces two mature mRNAs (fosB and ・fosB) by alternative splicing, and whose products differentially regulate the response to various brain stress. Our analyses of fosB-null mice and mutant mice which produce only one of the two mRNAs revealed that both of the two fosB mRNA products play distinct roles in control of the adult neurogenesis in hippocampal dentate gyrus through regulating expression of various genes, and thus suppressing epilepsy and depressive behavior.
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Research Products
(13 results)
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[Journal Article] fosB-Null Mice Display Impaired Adult Hippocampal Neurogenesis and Spontaneous Epilepsy with Depressive Behavior2013
Author(s)
Yutsudo N, Kamada T, Kajitani K, Nomaru H, Katogi A, Ohnishi YH, Ohnishi YN, Takase K, Sakumi K, Shigeto H, Nakabeppu Y
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Journal Title
Neuropsychopharmacology
Volume: 38(5)
Pages: 895-906
DOI
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