System evolution in chorate morphogenesis in view of gene evolution of noncoding exons

2012 Fiscal Year Final Research Report

• Project/Area Number: 23657159
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Evolutionary biology
• Research Institution: Kitasato University
• Principal Investigator: ITO Michihiko 北里大学, 理学部, 准教授 (90240994)
• Project Period (FY): 2011 – 2012
• Keywords: 脊椎動物 / 選択的プロモーター / エクソン / 遺伝子進化 / 退化 / 精巣形成 / 生殖細胞

Research Abstract

To understand how emergence and degeneration of noncoding exon 1 is involved in morphological evolution in chordates, a testis formation-related gene Dmrt1was analyzed using several chordate species. The results indicated that Dmrt1’s noncoding exon 1 might have emerged during vertebrate evolution, which could give the gene two types of promoters, contributing to divergence of expression patterns. However, it might have degenerated because of changes of DMRT1 functions intestis formation and maintenance during amniote evolution.

Research Products

• [Journal Article] 両生類・爬虫類・鳥類の性決定システムおよびその分子機構 (2013)
  • Author(s): 伊藤 道彦
  • Journal Title: 細胞工学 Volume: 32巻 Pages: 181-187
  • URL: http://gakken-mesh.jp/journal/detail/9784780901399.html
• [Journal Article] Apoptotic and survival signaling mediated through death receptor members during metamorphosis in the African clawed frog Xenopus laevis (2012)
  • Author(s): Ito,M.,Tamura,K.,Mawaribuchi,S.,and Takamatsu, N
  • Journal Title: Gen.Comp.Endocrinol Volume: 176 Pages: 461-464
  • DOI: DOI:10.1016/j.ygcen.2011.12.037
  • Peer Reviewed
• [Journal Article] Mawaribuchi,S.,Yoshimoto,S.,Ohashi,S.,Takamatsu,N.,and Ito,M (2012)
  • Author(s): Mawaribuchi,S.,Yoshimoto,S.,Ohashi,S.,Takamatsu,N.,and Ito,M
  • Journal Title: Chromosome Res Volume: 20 Pages: 139-151
  • DOI: DOI:10.1007/s10577-011-9265-9
  • Peer Reviewed
• [Presentation] Male sex-determining systems during vertebrate evolution? (2012)
  • Author(s): Ito,M
  • Organizer: Turnovers in sex-determination mechanisms
  • Place of Presentation: La Sage, Switzerland
  • Year and Date: 20120600
• [Presentation] Molecular evolution of veertebrate Dmrt1 orthlogues (2012)
  • Author(s): Ito,M., et al
  • Organizer: Sixth International Symposium on Vertebrate Sex Determination
  • Place of Presentation: Kona,USA
  • Year and Date: 20120400
• [Presentation] Opposite roles of DMRT1 and tsW-linked paralogue (2011)
  • Author(s): Ito,M., et al
  • Organizer: 北米比較内分泌学会
  • Place of Presentation: Ann Arbor,USA
  • Year and Date: 20110700
• [Remarks]
  • URL: http://www.kitasato-u.ac.jp/sci/resea/seibutsu/joho/index.htm