Reactivation of latently infected virus as a novel non-invasive stress marker

2013 Fiscal Year Final Research Report

• Project/Area Number: 23657170
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied anthropology
• Research Institution: The University of Tokyo
• Principal Investigator: ISHIDA Takafumi 東京大学, 理学(系)研究科(研究院), 教授 (20184533)
• Research Collaborator: TADAKARA Gento 東京大学, 大学院・理学系研究科, 博士課程
• Project Period (FY): 2011 – 2012
• Keywords: ストレス評価 / ウイルス / 非侵襲

Research Abstract

To search for novel non-invasive stress marker(s), reactivation of latently infected ubiquitous viruses and salivary alpha-amylase were monitored. The concentrations of salivary alpha-amylase among several animals such as elephants, chimpanzees, horses, were measurable with a simple machine produced for human amylase monitoring. Shedding pattern of the human gamma-herpesvirus (EBV) into saliva delayed the changes of alpha-amylase concentration; reactivation of EBV (or gamma-herpesvirus) is considered to be a medium-range stress marker.

Research Products

• [Journal Article] Hypertension Susceptibility Gene Prevalence in the Pacific Islands and Associations with Hypertension in Melanesia (2013)
  • Author(s): Furusawa, T., Naka, I., Yamauchi, T., Natsuhara, K., Eddie, R., Kimura, R., Nakazawa, M., Ishida, T., Inaoka, T., Matsumura, Y., Ataka, Y., Ohtsuka, R. and Ohashi, J
  • Journal Title: Journal of Human Genetics Volume: 58 Pages: 142-149
  • DOI: 10.1038/jhg.2012.147
  • Peer Reviewed
• [Journal Article] Extra-pair paternity confirmed in wild white-handed gibbons (2013)
  • Author(s): Barelli, C., Matsudaira, K., Wolf, T., Roos, C., Heistermann, M., Hodges, K., Ishida, T., Malaivijitnond, S. and Reichard, U.H
  • Journal Title: American Journal of Primatology Volume: 75 Pages: 1185-1195
  • DOI: 10.1002/ajp.22180
  • Peer Reviewed
• [Journal Article] The role of uncoupling protein 2 and 3 genes polymorphism and energy expenditure in obese Indonesian children (2013)
  • Author(s): Mexitalia, M., Yamauchi, T., Utari, A., Sjarif, D R., Subagio, H W., Soemantri, A. and Ishida, T
  • Journal Title: Journal of Pediatric Endocrinology Volume: 26 Pages: 441-447
  • DOI: 10.1515/jpem-2012-0311
  • Peer Reviewed
• [Journal Article] Molecular evidence for the introgression between Hylobates lar and H (2013)
  • Author(s): Matsudaira, K., Reichard, U., Malavijitnond, S. and Ishida, T
  • Journal Title: pileatus in the wild. Primates Volume: 54 Pages: 33-37
  • DOI: 10.1007/s10329-012-0323-5
  • Peer Reviewed
• [Journal Article] Low prevalence of Toxoplasma gondii infection among women in Northeastern Thailand (2013)
  • Author(s): Sakae, C., Natphopsuk, S., Settheetham-Ishida, W. and Ishida, T
  • Journal Title: Journal of Parasitology Volume: 99 Pages: 172-173
  • DOI: 10.1645/GE-3222.1
  • Peer Reviewed
• [Journal Article] A functional promoter polymorphism of the beta-2 adrenergic receptor gene (ADRB2) is associated with obesity in Oceanic populations (2013)
  • Author(s): Naka, I., Hikami, K., Nakayama, K., Koga, M., NIshida, N., Kimura, R., Furusawa, T., Natsuhara, K., Yamauchi, T., Nakazawa, M., Ataka, Y., Ishida, T., Inaoka, T., Munkhtulga, L., Iwamoto, S., Matsumura, Y., Ohtsuka, R. Tsuchiya, N. and Ohashi, J
  • Journal Title: International Journal of Obesity Volume: 37 Pages: 1204-1210
  • DOI: 10.1038/ijo.2012.206
  • Peer Reviewed
• [Journal Article] Risk factors for cervical cancer in northeastern Thailand : detailed analyses for the sexual and smoking behaviors (2012)
  • Author(s): Natphopsuk, S., Settheetham-Ishida, W., Sinawat, S., Pientong, C., Yuenyao, P. and Ishida, T
  • Journal Title: Asian Pacific J. Cancer Prev Volume: 13 Pages: 5489-5495
  • Peer Reviewed
• [Journal Article] Lineage-specific evolution of T-cell immunoglobulin and mucin domain 1 gene in the primates (2012)
  • Author(s): Ohtani, H., Naruse, T.K., Iwasaki, Y., Akari, H., Ishida, T., Matano, T. and Kimura, A
  • Journal Title: Immunogenetics Volume: 64 Pages: 669-678
  • DOI: 10.1007/s00251-012-0628-y
  • Peer Reviewed
• [Journal Article] DRD4 VNTR polymorphism in Oceanic populations (2012)
  • Author(s): Naka, I., Ohashi, J., Kimura, R., Furusawa, T., Yamauchi, T., Nakazawa, M., Natsuhara, K., Ataka, Y., Nishida, N., Ishida, T., Inaoka, T., Matsumura, Y. and Ohtsuka, R
  • Journal Title: Anthropological Science Volume: 120 Pages: 151-155
  • DOI: 10.1537/ase.110901
  • Peer Reviewed
• [Journal Article] The unstable CCTG repeat responsible for myotonic dystrophy type 2 originates from an AluSx element insertion into an early primate genome (2012)
  • Author(s): Kurosaki, T., Ueda, S., Ishida, T., Abe, K., Ohno, K. and Matsuura, T
  • Journal Title: PLos One Volume: 7 Pages: e38379
  • DOI: 10.1371/journal.pone.0038379
  • Peer Reviewed
• [Journal Article] Direct evidence for Toxoplasma gondii infection in a wild Japanese serow (Capricornis crispus) from mainland Japan (2012)
  • Author(s): Sakae, C. and Ishida, T
  • Journal Title: J. Parasitology Volume: 98 Pages: 224-225
  • DOI: 10.1645/GE-2881.1
  • Peer Reviewed
• [Journal Article] (2012) : Hepatitis E virus outbreak in monkey facility, Japan (2012)
  • Author(s): Yamamoto, H., Suzuki, J., Matsuda, A., Ishida, T., Ami, Y., Suzaki, Y., Adachi, I., Wakita, T., Takeda, N., Li, T.-C
  • Journal Title: Emerging Infectious Diseases Volume: 18(12) Pages: 2032-2034
  • URL: http://dx.doi.org/eid1812.120884
  • Peer Reviewed
• [Journal Article] High prevalence of an anti-hypertriglyceridemic variant of the MLXIPL gene in Central Asia (2011)
  • Author(s): Nakayama, K., Yanagisawa, Y., Ogawa, A., Ishizuka, Y., Munkhtulga, L., Charupoonphol, P., Supannnatas, S., Kuartei, S., Chimedregzen, U., Koda, Y., Ishida, T., Kagawa, Y. and Iwamoto, S
  • Journal Title: Journal of Human Genetics Volume: 56 Pages: 828-833
  • DOI: 10.1038/jhg.2011.109
  • Peer Reviewed
• [Journal Article] Genetic Risk of DNA Repair Gene Polymorphisms (XRCC1 and XRCC3) for High Risk Human Papillomavirus Negative Cervical Cancer in Northeast Thailand (2011)
  • Author(s): Settheetham-Ishida, W., Yuenyao, P., Natphopsuk, S., Settheetham, D. and Ishida, T
  • Journal Title: Asian Pacific J. Cancer Prev Volume: 12 Pages: 963-966
  • Peer Reviewed
• [Journal Article] Molecular evolution of immunoglobulin superfamily genes in primates (2011)
  • Author(s): Ohtani, H., Nakajima, T., Akari, H., Ishida, T. and Kimura, A
  • Journal Title: Immunogenetics Volume: 63 Pages: 417-428
  • DOI: 10.1007/s00251-011-0519-7
  • Peer Reviewed
• [Journal Article] The serum leptin level and body mass index in Melanesian and Micronesian Solomon Islanders : focus on genetic factors and urbanization (2011)
  • Author(s): Furusawa, T., Naka, I., Yamauchi, T., Kimura, R., Nakazawa, M., Ishida, T., Nishida, N., Eddie, R., Ohtsuka, R. and Ohashi, J
  • Journal Title: American Journal of Human Biology Volume: 23 Pages: 435-444
  • DOI: 10.1002/ajhb.21124
  • Peer Reviewed
• [Journal Article] Human papillomavirus genotype and cervical cancer in Northeast Thailand
  • Author(s): Natphopsuk, S., Settheetham-Ishida, W.,Pientong,C., Sinawat, S., Yuenyao, P. and Ishida, T
  • Journal Title: Asian Pacific Journal of Cancer Prevention Volume: (in press)
  • Peer Reviewed
• [Presentation] Current advances in gibbon phylogeny (2012)
  • Author(s): Matsudaira, K. and Ishida, T
  • Organizer: The 3rd International Symposium on Southeast Asian Primates Research : Diversity and Evolution of Asian Primates
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2012-08-25
• [Presentation] Stress and Immunity (2011)
  • Author(s): Ishida, T.
  • Organizer: The 40th Annual Meeting of the Physiological Society of Thailand, International Conference
  • Place of Presentation: Khon Kaen, Thailand
  • Year and Date: 2011-05-02
• [Remarks]
  • URL: http://www.biol.s.u-tokyo.ac.jp/users/anthro/lab.html