2012 Fiscal Year Final Research Report
Study on functional foods that associate with G protein-coupled receptors
| Project/Area Number |
23658109
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SATO Ryuichiro 東京大学, 大学院・農学生命科学研究科, 教授 (50187259)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMIZU Makoto 東京大学, 大学院・農学生命科学研究科, 助教 (40409008)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 食品機能 / Gタンパク質共役受容体 |
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| Research Abstract |
It is known that G protein-couple receptors (GPCR) with 7 transmembrane domains can bind specific intrinsic ligands and be involved in metabolic regulation. In terms of a G protein-couple receptor TGR5 that interacts with bile acids, we managed to identify a couple of chemical compounds derived from plants. Moreover, we attempted to establish different assay systems that are able to monitor ligand activities of various food factors for GPCRs.
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