2012 Fiscal Year Final Research Report
Establishment of confined rat model "Netakiri" and molecular nutrition to recover from "Netakiri"
| Project/Area Number |
23658111
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Nagoya University |
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Principal Investigator |
ODA Hiroakiy 名古屋大学, 生命農学研究科, 准教授 (20204208)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 寝たきり / 脂質代謝 / 肝障害 |
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| Research Abstract |
Bed rest confined condition, so called in Japanese “Netakiri” has been an important social issue in Japan. It is difficult that “Netakiri” people return to an independent lifestyle. Then we thought to look for food stuff to accelerate recovery from “Netakiri” condition. T o do these experiments, we have established confined rat model which is similar to “Netakiri” human. “Netakiri” rat model showed hypercholesterolemia and liver injury. The secretion rate of VLDL-cholesterol from liver was increased in “Natakiri” rats as compared to controls. The increased secretion of VLDL would explain the hypercholesterolemia. DNA microarray analysis indicated that genes related to cell cycles and apoptosis are changed. These result might explain the liver injury. Gene expression related to sulfur-containing amino acid metabolism was also changed. This change led to abnormal cholesterol or bile acid metabolism. The changed cholesterol and bile acid metabolism would lead hypercholesterolemia. Dietary egg white protein suppressed the hypercholesterolemia induced by “Netakiri” condition. And soy protein isolate suppressed both hypercholesterolemia and liver injury. These indicate that some dietary factors can ameliorate metabolic abnormality and liver injury induce by “Netakiri” condition.
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