2013 Fiscal Year Final Research Report

Molecular regulation of epigenetics of the cytochrome P450 genes by food chemicals

Research Project

Project/Area Number	23658116
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Food science
Research Institution	Kobe University
Principal Investigator	IMAISHI Hiromasa 神戸大学, 学内共同利用施設等, 教授 (50223318)
Project Period (FY)	2011 – 2013
Keywords	P450
Research Abstract	It is known that P450 which is a useful biological catalyst can carry out the monooxigenation of the medicine and chemicals.Especially P450 can carry out metabolic activation of various chemical substances which participate in the generation of cancer cells. We know that the chemical substance with has mutagenicity can increase the cancer cells in our body. In general, these mutagenic chemicals are metabolic activated by P450 monooxygenase. On the other hand, there is a little information about the mechanism for the activation of non-mutagenic chemicals. In this research, we show that the isothiocyanate which is a non-mutagenicity substance of food origin can regulate the total amount of mRNA of P450.