2012 Fiscal Year Final Research Report
Generation of rat iPS cells
| Project/Area Number |
23658227
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied animal science
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 発生工学 |
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| Research Abstract |
We tried to generate iPS cells from our transgenic rat having drug-inducible reprogramming factors. However, there were some difficulties in mating. Then, as a first step to generate iPS cells and to analyze the reprogramming mechanisms, I focused on Oct4-binding sites in the nanog gene which is a marker gene of ES cells. I identified novel 9 novel Oct4-binding sequences in the rat nanog gene.
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