2013 Fiscal Year Final Research Report
Dynamics of nuclear architecture involving in reprogramming of mouse somatic nuclear transfer embryos
| Project/Area Number |
23658228
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied animal science
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| Research Institution | Kinki University |
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Principal Investigator |
MITANI Tasuku 近畿大学, 先端技術総合研究所, 教授 (10322265)
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| Co-Investigator(Renkei-kenkyūsha) |
HARATA Masahiko 東北大学, 大学院・農学研究科, 准教授 (70218642)
TANABE Hideyuki 総合研究大学院大学, 先導科学研究科, 准教授 (50261178)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 体細胞核移植 / リプログラミング / クロマチンリモデリング / ヒストン |
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| Research Abstract |
This study examined the dynamics of chromatin composition in the early development of somatic cell nuclear transfer (SCNT) embryos. The results are summarized as follows: (1) histone composition of the SCNT embryos differs from that of the fertilized ones, (2) a certain histone variant is removed from chromatin by histone deacetylase (HDAC) inhibitors, and (3) responsiveness of histone modification and disposition depends on HDAC inhibitors and/or the types of cells.
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Research Products
(21 results)
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[Journal Article] Possible Role of ZPAC, Zygote-specific Proteasome Assembly Chaperone, during Spermatogenesis in the Mouse2014
Author(s)
Shimizu N, Ueno K, Kurita E, Shin SW, Nishihara T, Amano T, Anzai M, Kishigami S, Kato H, Mitani T, Hosoi Y, Matsumoto K
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Journal Title
J. Reprod. Dev
Volume: 60(印刷中)
Peer Reviewed
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[Journal Article] GSE is a maternal factor involved in active DNA demethylation in zygotes2013
Author(s)
Hatanaka Y, Shimizu N, Nishikawa S, Tokoro M, Shin SW, Nishihara T, Amano T, Anzai M, Kato H, Mitani T, Hosoi Y, Kishigami S, Matsumoto K
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Journal Title
PLoS One
Volume: 8
Pages: e60205
Peer Reviewed
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[Journal Article] Development of interspecies cloned embryos reconstituted with rabbit (Oryctolagus cuniculus) oocytes and cynomolgusmonkey (Macaca fascicularis) fibroblast cell nuclei2013
Author(s)
Yamochi T, Kida Y, Oh N, Ohta S, Amano T, Anzai M, Kato H, Kishigami S, Mitani T, Matsumoto K, Saeki K, Takenoshita M, Iritani A, Hosoi Y
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Journal Title
Zygote
Volume: 21
Pages: 358-366
Peer Reviewed
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[Presentation] GSE is a maternal factor for DNA demethylation in early embryos2012
Author(s)
Hatanaka Y, Shimizu N, Morita K, Nishikawa S, Nishihara T, Kato R, Takemoto A, Higuchi C, Amano T, Kishigami S, Anzai M, Kato H, Mitani T, Hosoi Y, Matsumoto K
Organizer
第35回日本分子生物学会年会
Place of Presentation
福岡市
Year and Date
2012-12-11
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[Presentation] マウス体細胞核移植卵子におけるヒストンH2A.Z の動態に及ぼすトリコスタチンA の影響2012
Author(s)
石川裕子, 恵本哲矢, 中家雅隆, 川口翔, 平野大起, 加藤博己, 安齋政幸, 岸上哲士, 入谷明, 細井美彦, 福田愛作, 森本義晴, 三谷匡
Organizer
第30回日本受精着床学会総会・学術講演会
Place of Presentation
大阪市
Year and Date
2012-08-31
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[Presentation] Dnmt1p ノックダウンマウスの解析2012
Author(s)
加藤博己, 明野美穂, 北村亮, 山口広生, 沼田雄基, 木島隆之, 安齋政幸, 三谷匡, 松本和也, 佐伯和弘, 細井美彦, 入谷明
Organizer
第30回日本受精着床学会総会・学術講演会
Place of Presentation
大阪市
Year and Date
2012-08-31
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