2012 Fiscal Year Final Research Report
Generation of artificial thymus using trans-differentiation potentials between skin and thymic epithelial cells
| Project/Area Number |
23658246
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
GOITSUKA Ryo 東京理科大学, 生命医科学研究所, 教授 (50301552)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 移植・再生医療 / 再生医学 / 細胞・組織 / 発生・分化 / 免疫学 |
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| Research Abstract |
Given that it has been demonstrated that thymic epithelial cells have a potential to trans-differentiate into skin epithelial stem cells when exposed to inductive skin microenvironment, these two epithelial cells appears to share similar regulatory mechanisms for stem cell maintenance and differentiation. We sought that there is a possibility to trans-differentiate skin epithelial cells into thymic epithelial cells, eventually to generate the artificial thymus from the skin for regenerative medical application. In the present study, we demonstrated that Meis1, a homeodomain family transcription factor expressed in postnatal thymic epithelial stem cells, is also expressed in skin epithelial stem cells. By applying Meis1 as a marker shared by skin and thymic epithelial stem cells, we may challenge to establish the above-mentioned method to generate the artificial thymus in near future.
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[Journal Article] Amelioration of collagen-induced arthritis by a novel S1P1antagonist with immunomodulatory activities2012
Author(s)
Fujii, Y., Hirayama, T., Ohtake, T., Ono, N., Inoue, T., Sakurai, T., Takayama, T., Matsumoto, K., Tsukahara, N., Hidano, S., Harima, N., Nakazawa, K., Igarashi, Y., and Goitsuka, R.
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Journal Title
J. Immunol.
Volume: 188(1)
Pages: 206-215
Peer Reviewed
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[Journal Article] Lymphopenia induced by a novel selective S1P1 antagonist structurally unrelated to S1P2012
Author(s)
Fujii, Y., Ohtake, H., Ono, N., Hara, T., Sakurai, T., Takahashi, S., Takayama, T., Fukasawa, Y., Shiozawa, F., Tsukahara, N., Hirayama, T., Igarashi, Y., and Goitsuka, R.
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Journal Title
Biochim. Biophys. Acta.
Volume: 1821(4)
Pages: 600-606
Peer Reviewed
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[Journal Article] Blocking S1P interaction with S1P1 receptor by a novel competitive S1P1-selective antagonist inhibits angiogenesis2012
Author(s)
Fujii, Y., Ueda, Y., Ohtake, H., Ono, N., Takayama, T., Nakazawa, K., Igarashi, Y. and Goitsuka, R.
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 419 (4)
Pages: 754-760
Peer Reviewed
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