2012 Fiscal Year Final Research Report
Studies on the outbreak mechanism of hereditary dilated cardiomyopathy in dogs
| Project/Area Number |
23658263
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Clinical veterinary science
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| Research Institution | Tottori University |
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Principal Investigator |
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| Research Collaborator |
有田 申二 山口大学, 大学院・連合獣医学研究科臨床獣医学, 専攻生
中嶋 美記 鳥取大学, 農学部獣医内科学研究室, 専攻生
阿波 利英 鳥取大学, 農学部獣医内科学研究室, 専攻生
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| Project Period (FY) |
2011 – 2012
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| Keywords | 慢性心不全 / 拡張型心筋症 / 白内障 / アメリカンコッカースパニエル / クリスタリン遺伝子 / 遺伝性疾患 / 犬 |
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| Research Abstract |
Clinical conditions of the dilated cardiomyopathy in the American Cocker spaniel (ACS) family developed dilated cardiomyopathy and a cataract were analyzed. Protein expressions and various gene analyses participating in outbreak of the dilated cardiomyopathy were analyzed. As a result, the outbreak of dilated cardiomyopathy in ACS family was found in this study. Outbreaks of cardiomyopathy and cataract were associated with the decrease of the expression level of Alpha B-crystallin (CRYAB) in the skeletal muscle. Single nucleotide polymorphisms of the amino acid non-coding regions of CRYAA or CRYAB gene were found, suggesting a relationship between cardiomyopathy and genetic polymorphism.
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