2012 Fiscal Year Final Research Report

Research on the design and synthesis of chiral NHC pincer ligands and their utility for asymmetric catalysis

Research Project

Project/Area Number	23659014
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Chemical pharmacy
Research Institution	Waseda University
Principal Investigator	NAKADA Masahisa 早稲田大学, 理工学術院, 教授 (50198131)
Project Period (FY)	2011 – 2012
Keywords	有機化学 / 配位子 / ピンサー型配位子 / 不斉触媒 / 不斉触媒反応
Research Abstract	A new chiral N-heterocyclic carbene (NHC) pincer-type ligand was synthesized. Its cationic platinum complex catalyzed an enantioselective cycloisomerization of a 1,5-ene-yne. A new preparation method of imidazolinium salts from the corresponding thioureas was developed. An asymmetric epoxidation catalyzed by a new iron (III) complex of a chiral C2-symmetric pincer-type ligand was discovered. Imidazolinium salts, precursors of chiral C2-symmetric NHC pincer-type ligands, were synthesized in high yields but were found to be unstable and difficult to convert to the corresponding transition metal complexes.