2011 Fiscal Year Final Research Report

Development of Multifunctional Catalyst Operated byπ-Complexation Toward the Efficient Production of Enantioenriched Tetrasubstitutedα-Amino Acids.

Research Project

Project/Area Number	23659015
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Chemical pharmacy
Research Institution	公益財団法人微生物化学研究会
Principal Investigator	SHIBASAKI Masakatsu 公益財団法人微生物化学研究会, 微生物化学研究所, 所長 (30112767)
Co-Investigator(Kenkyū-buntansha)	KUMAGAI Naoya 公益財団法人微生物化学研究会, 微生物化学研究所・有機合成研究部, 主任研究員 (40431887)
Project Period (FY)	2011
Keywords	π結合 / アミノ酸 / 不斉4置換炭素 / 4置換アミノ酸 / 不斉合成 / 立体転写
Research Abstract	Designed catalysts bearing an electron-poorπ-complexation unit was synthesized and evaluated in π-complexation capability with substrates having an electron-donating. π-complexation unit by NMR analysis. Whereas a model catalyst lacking catalytically active site as a Bronsted base produced aπ-complex, a catalyst armed with a catalytic functionality failed to form theπ-complex. A new design for properly separating theπ-complexation unit and the catalytic site would lead to an effective catalytic system.

(2 results)