2011 Fiscal Year Final Research Report
Creation of functional mutant interferon-alpha for increase of bioactivity and decease of side-effects
| Project/Area Number |
23659061
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Drug development chemistry
|
|---|
| Research Institution | 独立行政法人医薬基盤研究所 |
|---|
Principal Investigator |
KAMADA Haruhiko 独立行政法人医薬基盤研究所, サブプロジェクトリーダー (00324509)
|
|---|
| Project Period (FY) |
2011
|
| Keywords | 医薬分子設計 / バイオテクノロジー |
|---|
| Research Abstract |
In this study, we focused on lead discovery for new interferon(IFN) therapy using structural mutant, which increase the activity and decrease the side-effects in vivo. We obtained 38 IFNα8 mutants, which have different binding activities for IFN receptor to perform the screening from IFN mutant library. Among these mutants, we found 4 mutant IFNs have superior activities than wild-type IFNα8.In future, we will utilize these mutant IFNs to create a new biopharmaceuticals by analyzing the mechanisms of increasing activity.
|
