2012 Fiscal Year Final Research Report
MVB sorting system as a novel defense mechanism against toxicity of cadmium
| Project/Area Number |
23659062
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
NAGANUMA Akira 東北大学, 大学院・薬学研究科, 教授 (80155952)
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| Project Period (FY) |
2011 – 2012
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| Keywords | カドミウム / MVBソーティングシステム / 酵母 / 毒性軽減機構 / 液胞 |
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| Research Abstract |
We examined the relationship of each protein, which is a member of the MVB sorting system on endosome, and cadmium toxicity using yeast cells. Deletion of each gene for all member protein of the system conferred hypersensitivity to cadmium toxicity. This result suggested that certain substrate protein(s) of this system plays a role in reduction of cadmium toxicity. Moreover, it was indicated that the substrate protein(s) is transported to the endosome through Golgi body from endoplasmic reticulum.
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