2013 Fiscal Year Final Research Report
Prediction of the drug incompatibility based on the evidence of organic chemistry
| Project/Area Number |
23659087
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OSHITARI Tetsuta 帝京大学, 薬学部, 准教授 (00279043)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 配合変化 / 有機化学 / メロペネム / β-ラクタム系抗生物質 / L-システイン / SH基 / 求核置換反応 / 細胞障害性 |
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| Research Abstract |
It is well known that after meropenem hydrate (MEPM) injection and amino acid infusions are mixed, the MEPM residual ratio sequentially decreases. This incompatibility is probably due to the nucleophilic attack to the beta-lactam ring of MEPM by L-cysteine (L-Cys) present in the amino acid infusion. Through the MEPM and L-Cys incompatibility test, L-Cys has been identified as the main cause of incompatibility between MEPM injection and amino acid infusions.
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[Presentation] カルバペネム系抗生物質とL-システインの配合変化物における細胞生存率への影響2014
Author(s)
中川 幸子, 板垣 文雄, 飯島 亮介, 忍足 鉄太, 高橋 秀依, 夏苅 英昭, 油井 聡, 鈴木 るね, 関谷 朱美, 西 優, 山元 孝俊, 渡邊 真知子
Organizer
第22回クリニカルファーマシーシンポジウム
Place of Presentation
東京
Year and Date
20140628-29
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