2012 Fiscal Year Final Research Report
Experimental approach for direct transformation of GABAergic neurons
Project/Area Number |
23659092
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
General anatomy (including Histology/Embryology)
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Research Institution | University of Fukui |
Principal Investigator |
SATO Makoto 福井大学, 医学部, 教授 (10222019)
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Co-Investigator(Kenkyū-buntansha) |
KURODA Kazuki 福井大学, 医学部, 助教 (60557966)
KOMADA Munekazu 愛知学院大学, 歯学部, 助教 (90523994)
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Project Period (FY) |
2011 – 2012
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Keywords | 解剖学 / 分化 / 細胞 / 組織 / 神経科学 |
Research Abstract |
(1) Cortical neurons that had been transfected with Ptf1a expressing vector migrated tangentially into the cortex, of which migratory behavior is typical for GABAergic neurons. (2)Ptf1a expression did not result in transformation of glutamatergic neurons into GABAergic neurons; no specific GABAergic neuronal markers were newly expressed in glutamatergic neurons by Ptf1a expression. (3) We collected RNAs from Ptf1a expressed neurons and searched for any Ptf1a-induced genes, then we identified several candidate genes.
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[Journal Article] WAVE2-Abi2 complex controls growth cone activity and regulates the multipolar-bipolar transition as well as the initiation of glia-guided migration2013
Author(s)
Xie, M.-J., Yagi, H., Kuroda, K., Wang C.-C., Komada, M., Zhao, H., Sakakibara, A., Miyata, T., Nagata, K., Oka, Y., Iguchi, T. and Sato, M
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Journal Title
Cerebral Cortex
Volume: 23(6)
Pages: 1410-1423
Peer Reviewed
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[Journal Article] Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective neuronal migration and neuronal circuit formation in lissencephaly2013
Author(s)
Toba, S., Tamura, Y., Kumamoto, K., Yamada, M., Takao, K., Hattori, S., Miyakawa, T., Kataoka, Y., Azuma, M.,Hayasaka, K., Amamoto, M., Tominaga, K., Wynshaw-Boris, A., Wanibuchi, H., Oka, Y., Sato, M., Kato, M. and Hirotsune, S.
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Journal Title
Sci. Rep
Volume: 3
Pages: 1224
Peer Reviewed
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[Journal Article] Long-term oxytocin administration improves social behaviors in a girl with autistic disorder. (case report)2012
Author(s)
Kosaka, H., Munesue, T., Ishitobi, M., Asano, M., Omori, M., Sato, M., Tomoda, A. and Wada, Y
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Journal Title
BMC Psychiatry
Volume: 12(1)
Pages: 110
Peer Reviewed
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[Journal Article] Activation of Aurora-A is essential for neuronal migration via modulation of microtubule organization2012
Author(s)
Takitoh, T., Kumamoto, K., Wang C.-C., Sato, M., Toba, S., Wynshaw-Boris, A. and Hirotsune, S
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Journal Title
J. Neurosci
Volume: 32(32)
Pages: 11050-11066
Peer Reviewed
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[Journal Article] Effects of antidepressants and mood stabilizers on serum levels of adiponectin2012
Author(s)
Omata, N., Murata, T., Narita, K., Maruoka, N., Mitsuya, H., Mita, K., Nishimoto, T., Sato, M. and Wada, Y
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Journal Title
NeuroEndocrinol. Lett.
Volume: 33(1)
Pages: 1-2
Peer Reviewed
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[Journal Article] Maternal bisphenol A oral dosing relates to the acceleration of neurogenesis in the developing neocortex of mouse fetuses2012
Author(s)
Komada, M., Asai, Y ., Morii, M., Matsuki, M., Sato, M. and Nagao, T
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Journal Title
Toxicology.
Volume: 16;295(1-3)
Pages: 31-8
Peer Reviewed
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[Journal Article] GPR98/Gpr98 Gene Is Involved in the Regulation of Human and Mouse Bone Mineral Density2012
Author(s)
Urano, T., Shiraki, M,. Yagi, H., Ito, M., Sasaki, N., Sato, M., Ouchi, Y . and Inoue, S
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Journal Title
J. Clin. Endocrinol. Metab
Volume: 97(4)
Pages: E565-74
Peer Reviewed
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[Presentation] Filip is involved in the morphological control of dendritic spine through actomyosin regulation2012
Author(s)
Yagi, H., Kuroda, K., Xie, M.-J. Ikeda, H., Iguchi, T., Komada, M., Murase K., Okabe M., Noguchi, K. and Sato, M
Organizer
ポスター(636.11/B30) Society For Neuroscience 2012
Place of Presentation
ニューオリンズ(U.S.A)
Year and Date
2012-10-16
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[Presentation] A2-pancortins especially Pancortin-4, are involved in the neuronal cell desth after the ischemic stroke during the growth period2012
Author(s)
Wang, C.-C., Kuroda, K., Xie, M.-J., Oka, Y., Iguchi, T., Matsuyama, T., and Sato, M
Organizer
ポ ス タ ー (P02-1) The 11thBiennial Meeting of the Asian-Pacific Society for Neurochemistry / 55thAnnual Meeting of the Japanese Society for Neurochemistry
Place of Presentation
神戸
Year and Date
2012-09-30
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[Presentation] Analyses on the potential candidates of collateral branch inducing factor that are specifically expressed in the targets of axon collaterals from the corticospinal projection.2012
Author(s)
Iguchi, T., Oka, Y., Kuroda, K., Wang, C.-C., Xie, M.-J., Yagi, H., and Sato, M
Organizer
ポスター(P01-14)The 11thBiennial Meeting of the Asian-Pacific Society for Neurochemistry / 55thAnnual Meeting of the Japanese Society for Neurochemistry
Place of Presentation
神戸
Year and Date
2012-09-29
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[Presentation] FILIP-related molecule controls spine maturation in the hippcampal neuron via non-muscle myosin llb2012
Author(s)
Kuroda, K., Yagi, H., Xie, M.-J., Oka, Y., Iguchi, T., and Sato, M
Organizer
ポスター(P01-36)The 11thBiennial Meeting of the Asian-Pacific Society for Neurochemistry / 55thAnnual Meeting of the Japanese Society for Neurochemistry
Place of Presentation
神戸
Year and Date
2012-09-29
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[Presentation] Dendritic growth cone activities, regulated by Abl kinase and Cdk5 via WAVE2-Abi2, are essential for completing multipolar-bipolar transition and starting glia-guided locomotion2011
Author(s)
Xie, M.-J., Yagi, H., Kuroda, K., Wang C.-C., Komada, M., Iguchi, T. and Sato, M.
Organizer
ポスター(A4 540.04)Society For Neuroscience 201
Place of Presentation
ワシントン (U.S.A)
Year and Date
2011-11-15
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