2012 Fiscal Year Final Research Report
Qualitative improvement of aged eggs and development of technologies supporting ART at later ages
| Project/Area Number |
23659107
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KURIHARA Hiroki 東京大学, 大学院・医学系研究科, 教授 (20221947)
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| Co-Investigator(Renkei-kenkyūsha) |
KURIHARA Yukiko 東京大学, 大学院・医学系研究科, 講師 (80345040)
UCHIJIMA Yasunobu 東京大学, 大学院・医学系研究科, 助手 (90272426)
KAWAMURA Yumiko 東京大学, 大学院・医学系研究科, 特任研究員 (70599779)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 生殖医学 / 老化 / 卵子 / 体外受精 / ミトコンドリア / サーチュイン遺伝子 |
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| Research Abstract |
Changes in women’s life styles have lead to the tendency of late childbearing, requiring ART at later ages. However, oxidative stress and decreased mitochondrial function are supposed to cause the deterioration of eggs with increasing age. In this study, we found that mitochondrial NAD+-dependent deacetylase Sirt3 may be involved in mechanisms underlying the deterioration and introduction of Sirt3 may improve the post-fertilization development. Furthermore, we established transgenic mice conditionally expressing Sirt3 in specific cell types including oocytes and eggs, whose phenotype is being analyzed.
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[Journal Article] Resistin-like molecule βis abundantly expressed in foam cells and is involved in atherosclerosis development2013
Author(s)
Kushiyama A, Sakoda H, Oue N, Okubo M,Nakatsu Y, Ono H, Fukushima T, Kamata H,Nishimura F, Kikuchi T, Fujishiro M,Nishiyama K, Aburatani H, Kushiyama S,Iizuka M, Taki N, Encinas J, Sentani K,Ogonuki N, Ogura A, Kawazu S, Yasui W,Higashi Y, Kurihara H, Katagiri HvAsano T.
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Journal Title
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume: 113
Pages: 301546
DOI
Peer Reviewed
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[Journal Article] A soluble form of LMIR5/CD300b amplifies lipopolysaccharide-induced lethal inflammation in sepsis.2012
Author(s)
Yamanishi Y, Takahashi M, Izawa K,Isobe M, Ito S, Tsuchiya A, Maehara A,Kaitani A, Uchida T, Togami K, Enomoto Y,Nakahara F, Oki T, Kajikawa M, Kurihara H,Kitamura T, Kitaura J.
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Journal Title
Journal of Immunology
Volume: 189
Pages: 1773-1779
DOI
Peer Reviewed
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[Journal Article] Xanthineoxidoreductase is involved in macrophagefoam cell formation and atherosclerosisdevelopment.2012
Author(s)
Kushiyama A, Okubo H, Sakoda H, KikuchiT, Fujishiro M, Sato H, Kushiyama S,Iwashita M, Nishimura F, Fukushima T,Nakatsu Y, Kamata H, Kawazu S, Higashi Y,Kurihara H, Asano T.
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Journal Title
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume: 32
Pages: 291-298
DOI
Peer Reviewed
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[Journal Article] Naratriptan mitigates CGRP1-associated motor neuron degeneration causedby an expanded polyglutamine repeat tract.2012
Author(s)
Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Iida M, Ishigaki S, Fujioka Y,Matsumoto S, Miyazaki Y, Tanaka F, Kurihara H, Sobue G.
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Journal Title
Nature Medicine
Volume: 18
Pages: 1531-1538
DOI
Peer Reviewed
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[Journal Article] Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model.2012
Author(s)
Nakatsu Y, Otani Y, Sakoda H, Zhang J,Guo Y, Okubo H, Kushiyama A, Fujishiro M,Kikuch T, Fukushima T, Ohno H, Tsuchiya Y,Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Takahashi S, Kurihara H,Uchida T, Asano T.
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Journal Title
The Journal of Biological Chemistry
Volume: 287
Pages: 44526-44535
DOI
Peer Reviewed
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[Journal Article] Preotic neural crest cells contribute to coronary artery smooth muscle involving endothelin signaling.2012
Author(s)
Arima Y, Miyagawa-Tomita S, Maeda K,Asai R, Seya D, Minoux M, Rijli FM,Nishiyama K, Kim KS, Uchijima Y, Ogawa H,Kurihara Y, Kurihara H.
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Journal Title
Nature Communications
Volume: 3
Pages: 1267
DOI
Peer Reviewed
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[Journal Article] Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and atherosclerosis development.2012
Author(s)
Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S,Iwashita M, Nishimura F, Fukushima T,Nakatsu Y, Kamata H, Kawazu S, Higashi Y,Kurihara H, Asano T.
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 32
Pages: 291-298
DOI
Peer Reviewed
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[Journal Article] Angiogenic morphogenesis driven by dynamic and heterogeneous collectiveendothelial movement2011
Author(s)
Arima S, Nishiyama K, Ko T, Arima Y,Hakozaki Y, Sugihara K, Koseki H, Uchijima Y, Kurihara Y, Kurihara H., Koichi Nishiyama
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Journal Title
Development
Volume: 138
Pages: 4763-4776
DOI
Peer Reviewed
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