2013 Fiscal Year Final Research Report
Development of method for neural activity manipulation using melanopsin
| Project/Area Number |
23659128
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Nagoya University (2012-2013)
National Institute for Physiological Sciences (2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小泉 周 生理学研究所, 准教授 (10296551)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 光遺伝学 / トランスジェニックマウス / スライスパッチクランプ / オレキシン |
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| Research Abstract |
Melanopsin is a light-activated membrane protein which is expressed in the part of ganglion cell in the retina. Melanopsin is activated by the blue light around 470 nm. Melanopsin send signal to intracellular via Gq protein. Melanopsin has higher light sensitivity compare with Channelrhodopsin. And the effect is lasted for long time. In this study, we tried to control specific type of neurons for long time by expressing melanopsin. We succeeded with establishing control method of neural activity by using weaker light.
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[Journal Article] Greatly increased numbers of histamine cells in human narcolepsy with cataplexy2013
Author(s)
John J, Thannickal TC, McGregor R, Ramanathan L, Ohtsu H, Nishino S, Sakai N, Yamanaka A, Stone C, Cornford M, Siegel JM
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Journal Title
Ann Neurol
Volume: 74(6)
Pages: 786-93
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