2012 Fiscal Year Final Research Report

Functional analyses of novel mitochondrial fusion inhibitor HPGBin the regulation of heart and metabolism

Research Project

Project/Area Number	23659143
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	General pharmacology
Research Institution	Hyogo University of Health Sciences
Principal Investigator	BABA Akemichi 兵庫医療大学, 薬学部, 教授 (70107100)
Co-Investigator(Kenkyū-buntansha)	SHINTANI Norihito 大阪大学, 薬学研究科, 准教授 (10335367) HAYATA Atsuko 大阪大学, 連合小児発達学研究科, 助教 (70390812)
Project Period (FY)	2011 – 2012
Keywords	シグナル情報伝達系 / ミトコンドリア / 2 型糖尿病 / 酸化ストレス
Research Abstract	This study performed functional analyses on a novel gene named hyperplasia-associated gene of pancreatic β-cell (HPGB). We confirmed that HPGB functions as an endogenous mitochondrial fusion inhibitor etc., found its possible roles in the regulation of oxidative stress and mitophagy, and identified amino acids involved in its fusion inhibition activity. In addition, we generated transgenic mice overexpressing HPGB in the pancreatic β-cell or cardiac muscle. Phenotypic analyses of the β-cell transgenic mice suggested that HPGB enhances β-cell proliferation and suppresses oxidative lipids accumulation in β-cells under the type 2 diabetic condition. Taken together, this study firstly revealed the physiopathological significance of HPGB.

(4 results)