2012 Fiscal Year Final Research Report
Molecular Mechanism of Unconventional Secretory Pathway for "Leaderless" Proteins
| Project/Area Number |
23659154
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 分泌タンパク質 / シグナルペプチド / 非古典的分泌経路 / ナルディライジン |
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| Research Abstract |
Several “leaderless” proteins, which lack a consensus signal sequence, are secreted through unconventional secretory pathways. The mechanism by which leaderless proteins cross cell membranes is poorly understood. We have shown that nardilysin (N-arginine dibasic convertase: NRDc), a leaderless zinc peptidase, has localization-dependent multiple functions. Here, we demonstrate that the phosphorylation of NRDc is involved in the secretion.
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[Journal Article] Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signaling via enhanced ectodomain shedding of TNF-a2012
Author(s)
Kanda K, Komekado H, Sawabu T, Ishizu S, Nakanishi Y, Nakatsuji M, Akitake-Kawano R, Ohno M, Hiraoka Y, Kawada M, Kawada K, Sakai Y, Matsumoto K, Kunichika M, Kimura T, Seno H*, Nishi E*, and ChibaT
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Journal Title
EMBO Mol Med
Volume: 4
Pages: 396-411
DOI
Peer Reviewed
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[Presentation] Nardilysin, an Activator of Ectodomain Shedding, is a Novel and Potent Biomarker for Acute Coronary Syndrome2013
Author(s)
Ohno M, Watanabe S, Hiraoka Y, Matsuoka T, Nishi K, Saijo S, Sakamoto J, Chen PM, Inoue K, Kita T, Kimura T, Nishi E
Organizer
第77回日本循環器学会総会
Place of Presentation
横浜
Year and Date
20130315-17
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[Presentation] NRDc regulates circulatory dynamics through modulating sinus node automaticity and cardiac sympathetic innervation2012
Author(s)
Ohno M, Hiraoka Y, Matsuura H, Matsuoka T, Nishi K, Saijo S, Sakamoto J, Chen PM, Kita T, Kimura T, Nishi E
Organizer
Neuro-Vascular Wiring Symposium2012
Place of Presentation
Nara
Year and Date
20121112-13
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[Presentation] Nardilysin, an activator of ectodomain shedding, is a novel and potent biomarker for acute Nardilysin, an activator of ectodomain shedding, is a novel and potent biomarker for acute Nardilysin, an activator of ectodomain shedding, is a novel and potent bi2012
Author(s)
Ohno M, Watanabe S, Hiraoka Y, Matsuoka T, Nishi K, Saijo S, Kita T, Nishi E, Kimura T.
Organizer
ESC Congress 2012
Place of Presentation
Munich(Germany)
Year and Date
20120825-29
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