2012 Fiscal Year Final Research Report
The brain regeneration using chemotactic stimulation with favorable chemoattractant factor for autologous tissue stem cells
| Project/Area Number |
23659164
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kurume University |
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Principal Investigator |
ITO Takahiko 久留米大学, 医学部, 講師 (20309842)
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| Co-Investigator(Kenkyū-buntansha) |
MISHIMA Yasunori 久留米大学, 医学部, 准教授 (30258470)
ITO Asuka 久留米大学, 医学部, 助教 (20412538)
KAMEYAMA Naomitsu 久留米大学, 医学部, 助教 (80529511)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 再生医学 / 走化因子 / 遊走能 |
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| Research Abstract |
The aim of this project is for regeneration of brain tissue using stem cell migration from undamaged tissue to damaged tissue,that has been implanted high affinity scaffold. We made chemoattractant cocktail for stem cell migration. We confirmed that the cocktail accelerated stem cells migration. And we fabricated nano particles, which can release chemotactic factor long lasting, over 42 days. Finally, we fabricated scaffold. Although the scaffold had appropriate pore size for cell adhesion and growing, scaffold materials had cytotoxicity against stem cells. Cytotoxicity has been improving.
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