2012 Fiscal Year Final Research Report
Foundational approach for next-generation personalized cancer therapywith molecular target agents
| Project/Area Number |
23659196
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Hokkaido University |
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Principal Investigator |
OHBA Yusuke 北海道大学, 医学(系)研究科(研究院), 教授 (30333503)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 分子標的治療薬 / フェルスター共鳴エネルギー移動 |
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| Research Abstract |
With the use of a biosensor based on the principle of Forster resonance energy transfer, we isolated imatinib-resistant cells of Ph-positive acute lymphoid leukemia and explored their properties. Twenty-four signaling pathways were found activated in the resistant cells, among which inhibition of the mevalonate pathway was revealed effective in preventing repopulation of such resistant cells. These results thereby indicate that the combined application of statin may serve to cure Ph-positive acute lymphoid leukemia as well as imatinib-resistant chronic myeloid leukemia.
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[Journal Article] Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB12012
Author(s)
S. Chiba, M. Baghdadi, H. Akiba, H.Yoshiyama, I. Kinoshita, H. Dosaka-Akita, Y. Fujioka, Y. Ohba, J.V. Gorman, J.D. Colgan, M. Hirashima, T. Uede, A. Takaoka, H.Yagita and M. Jinushi
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Journal Title
Nat. Immunol
Volume: 13
Pages: 832-842
Peer Reviewed
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[Journal Article] DJ-1 associates with synaptic membranes2011
Author(s)
Y. Usami, T. Hatano, S. Imai, S.I. Kubo, S.Sato, S. Saiki, Y. Fujioka, Y. Ohba, F. Sato, M. Funayama, H. Eguchi, K. Shiba, H. Ariga, J. Shen and N. Hattori
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Journal Title
Neurobiol. Dis
Volume: 43
Pages: 651-662
Peer Reviewed
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[Journal Article] Induction of Colonic Regulatory T Cells by IndigenousClostridium Species2011
Author(s)
K. Atarashi, T. Tanoue, T. Shima, A. Imaoka, T. Kuwahara, Y. Momose, G. Cheng, S. Yamasaki, T. Saito, Y. Ohba, T. Taniguchi, K. Takeda, S. Hori, I.I. Ivanov, Y. Umesaki, K. Itoh and K. Honda
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Journal Title
Science
Volume: 331
Pages: 337-341
Peer Reviewed
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[Journal Article] ZAPS is a potent stimulator of RIG-I-mediated signaling for antiviral response2011
Author(s)
S. Hayakawa, S. Shiratori, H. Yamato, T.Kameyama, C. Kitatsuji, F. Kashigi, S. Goto, S. Kameoka, D. Fujikura, T. Yamada, T. Mizutani, M. Kazumata, M. Sato, J. Tanaka, M. Asaka, Y. Ohba, T. Miyazaki, M. Imamura and A. Takaoka
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Journal Title
Nat. Immunol
Volume: 12
Pages: 37-44
Peer Reviewed
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