Molecular mechanism of pathogenic network for the onset of joint ankylosis with psoriatic dermatitis

2012 Fiscal Year Final Research Report

• Project/Area Number: 23659198
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: Tohoku University
• Principal Investigator: ONO Masao 東北大学, 大学院・医学系研究科, 教授 (20302218)
• Project Period (FY): 2011 – 2012
• Keywords: 強直症 / 皮膚炎 / IL-17 / 疾患モデル / 治療実験 / 抗サイトカイン療法

Research Abstract

Ankylosing arthropathy, such as ankylosing spondylitis, psoriatic arthritis, and so forth, are intractable joint diseases with present therapeutic approaches to other arthropathic disorders. To develop a new effective approach to ankylosing arthropathy, it is necessary to clarify an essential pathogenic mechanism of ankylosis and to obtain evidence for efficacy of a new therapeutic approach in an animal disease model. My previous study had characterized a proper mouse model for the study of human ankylosing diseases. The present study using experimental strains of mice with spontaneous onset of ankylosis showed genetic association of the ankylosis onset, pathogenic contribution of testis to male preponderance of this onset, histopathological characteristics of early to late phases after the ankylosis onset, and therapeutic efficacy of anti-IL-17 administration.

Research Products

• [Journal Article] A novel autoantibody against fibronectin leucine-rich transmembrane protein 2 expressed on the endothelial cell surface identified by retroviral vector system in systemic lupus erythematosus (2012)
  • Author(s): Shirai T, Fujii H, Ono M, Nakamura K, Watanabe R, Tajima Y, Takasawa N, Ishii T, Harigae H
  • Journal Title: Arthritis Res Ther Volume: 14(4) Pages: R157
  • Peer Reviewed
• [Journal Article] Bach1 is critical for the transformation of mouse embryonic fibroblasts by Ras(V12) and maintains ERK signaling (2012)
  • Author(s): Nakanome A, Brydun A, Matsumoto M, Ota K, Funayama R, Nakayama K, Ono M, Shiga K, Kobayashi T, Igarashi K
  • Journal Title: Oncogene
  • DOI: doi:10.1038
  • Peer Reviewed
• [Journal Article] Presumptive role of129 strain-derived Sle16 locus in rheumatoid arthritis in a new mouse model with Fcγ receptor type IIb-deficient C57BL/6 genetic background (2011)
  • Author(s): Sato-Hayashizaki A, Ohtsuji M, Lin Q, Hou R, Ohtsuji N, Nishikawa K, Tsurui H, Sudo K, Ono M, Izui S, Shirai T, Takai T, Nishimura H, Hirose S
  • Journal Title: Arthritis Rheum Volume: 63 Pages: 2930-2938
  • Peer Reviewed
• [Journal Article] Indispensable roles ofOX40L-derived signal and epistatic genetic effect in immune-mediated pathogenesis of spontaneous pulmonary hypertension (2011)
  • Author(s): Rabieyousefi M, Soroosh P, Satoh K, Date F, Ishii N, Yamashita M, Oka M, McMurtry IF, Shimokawa H, Nose M, Sugamura K, Ono M
  • Journal Title: BMC Immunology Volume: 12 Pages: 67-78
  • Peer Reviewed
• [Journal Article] Evaluation of antitumor effects following tumor necrosis factor-α gene delivery using nanobubbles and ultrasound (2011)
  • Author(s): Horie S, Watanabe Y, Ono M, Mori S, Kodama T
  • Journal Title: Cancer Sci Volume: 102 Pages: 2082-2089
  • Peer Reviewed
• [Presentation] 動物モデルの関節強直症に対する抗IL-17抗体投与の抑制効果 (2011)
  • Author(s): 海老原伸、小野栄夫
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-28
• [Presentation] 動物モデルの関節強直症に対する抗IL-17抗体投与の予防・治療効果 (2011)
  • Author(s): 海老原伸、小野栄夫
  • Organizer: 第55回日本リウマチ学会総会・学術集会
  • Place of Presentation: 神戸国際センター
  • Year and Date: 2011-07-18