2013 Fiscal Year Final Research Report
Development of new therapeutic strategies for regulating macrophage activation by natural compounds
| Project/Area Number |
23659204
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKASHITA Naomi 徳島大学, ヘルスバイオサイエンス研究部, 教授 (90284752)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJIWARA Yukio 熊本大学, 生命科学研究部, 助教 (70452886)
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| Project Period (FY) |
2011 – 2013
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| Keywords | マクロファージ / 古典的活性化 / オルタナティブ活性化 / 天然化合物 / corosolic acid / STAT3 |
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| Research Abstract |
Macrophages are variously activated in disease environment. For example, M1-activated macrophages are involved in obesity and atherosclerosis, whereas M2-activated tumor-associated macrophages promote tumor progression. To develop new therapeutic strategies we identified several compounds that regulate M1- or M2-activation of macrophages by screening the library of natural compounds. Among them, colosolic acid and onionin A suppressed tumor progression by means of suppressing STAT3 activation. These two compounds significantly suppressed subcutaneous tumor development and lung metastasis in a murine sarcoma model. Through these results, application of colosolic acid and onionin A is considered a potential new anticancer therapy targeting macrophage activation.
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[Journal Article] Overexpression of CD163, CD204 and CD206 on alveolar macrophages in the lungs of patients with severe chronic obstructive pulmonary disease2014
Author(s)
Kaku Y, Imaoka H, Morimatsu Y, Komohara Y, Ohnishi K, Oda H, Takenaka S, Matsuoka M, Kawayama T, Takeya M, Hoshino T
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Journal Title
PLoS One
Volume: 9
Pages: e87400
Peer Reviewed
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[Journal Article] a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo2013
Author(s)
Eguchi K, Fujiwara Y, Hayashida A, Horlad H, Kato H, Rotinsulu H, Losung F, Mangindaan RE, de Voogd NJ, Takeya M, Tsukamoto S. Manzamine A
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Journal Title
Bioorg Med Chem
Volume: 21
Pages: 3831-3838
Peer Reviewed
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[Journal Article] Apocynin suppresses the progression of atherosclerosis in apoE-deficient mice by inactivation of macrophages2013
Author(s)
Kinoshita H, Matsumura T, Ishii N, Fukuda K, Senokuchi T, Motoshima H, Kondo T, Taketa K, Kawasaki S, Hanatani S, Takeya M, Nishikawa T, Araki E
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Journal Title
Biochem Biophys Res Commun
Volume: 431
Pages: 124-130
Peer Reviewed
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[Journal Article] Tomatidine, a tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in apoE-deficient mice by inhibiting ACAT2012
Author(s)
Fujiwara Y, Kiyota N, Tsurushima K, Yoshitomi M, Horlad H, Ikeda T, Nohara T, Takeya M, Nagai R
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Journal Title
J Agric Food Chem
Volume: 60
Pages: 2472-2479
Peer Reviewed
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[Journal Article] A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein-E deficient mice2012
Author(s)
Matsubara J, Sugamura K, Nakamura T, Fujiwara Y, Akiyama E, Kurokawa H, Nozaki T, Ohba K, Konishi M, Maeda H, Izumiya Y, Kaikita K, Sumida H, Jinnouchi H, Matsui K, Kim-Mitsuyama S, Takeya M, Ogawa H
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Journal Title
J Am Coll Cardiol
Volume: 59
Pages: 265-276
Peer Reviewed
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[Journal Article] M2 macrophage/microglial cells induce activation of Stat3 in primary central nervous system lymphoma2011
Author(s)
Komohara Y, Horlad H, Ohnishi K, Ohta K, Makino K, Hondo H, Yamanaka R, Kajiwara K, Saito T, Kuratsu J, Takeya M
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Journal Title
J Clin Exp Hematopathol
Volume: 51
Pages: 93-99
Peer Reviewed
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[Journal Article] Garlicnin A from the fraction regulating macrophage activation of Allium sativum2011
Author(s)
El-Aasr M, Fujiwara Y, Takeya M, Ono M, Nakano D, Okawa M, Kinjo J, Ikeda T, Miyashita H, Yoshimitsu H, Nohara T
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Journal Title
Chem Pharm Bull (Tokyo)
Volume: 59
Pages: 1340-1343
Peer Reviewed
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[Journal Article] Natural compounds containing a catechol group enhance the formation of N_ε -(carboxymethyl)lysine of the Maillard reaction2011
Author(s)
Fujiwara Y, Kiyota N, Tsurushima K, Yoshitomi M, Mera K, Sakashita N, Takeya M, Ikeda T, Araki T, Nohara T, Nagai R
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Journal Title
Free Radic Biol Med
Volume: 50
Pages: 883-891
Peer Reviewed
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