2012 Fiscal Year Final Research Report
Analysis of novel host antiviral factors
| Project/Area Number |
23659231
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Osaka University |
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Principal Investigator |
SAITOH Tatsuya 大阪大学, 免疫学フロンティア研究センター, 特任准教授 (60456936)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 感染防御 / 自然免疫 / レトロウイルス |
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| Research Abstract |
HIV-1 and MLV are causative agents of AIDS and murine cancer, respectively. Innate immune system protects hosts from infection of HIV-1 and MLV. In the present study, we have demonstrated molecular mechanisms underlying innate immune responses to these retroviruses.
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[Journal Article] Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-12012
Author(s)
Saitoh T, Komano J, Saitoh Y, Misawa T, Takahama M, Kozaki T, Uehata T, Iwasaki H, Omori H, Yamaoka S, Yamamoto N, Akira S
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Journal Title
Cell Host Microbe
Volume: 12
Pages: 109-116
Peer Reviewed
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[Journal Article] (*Co-corresponding authors).Zinc-finger antiviral protein mediates RIG-I-like-receptor-independent antiviral response to murine leukemia virus
Author(s)
Lee H, Komano J, Saitoh Y, Yamaoka S, Kozaki T, Misawa T, Takahama M, Satoh T, Takeuchi O, Yamamoto N, Matsuura Y, Saitoh T*, Akira S*
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Journal Title
Proc Natl Acad Sci U S A
Volume: (in press)
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