2012 Fiscal Year Final Research Report
Investigation of the molecular targets for regulation of HIV-1 expression in latently infected cells
| Project/Area Number |
23659233
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Kagoshima University |
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Principal Investigator |
BABA Masanori 鹿児島大学, 大学院医歯学総合研究科, 教授 (70181039)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Mika 鹿児島大学, 大学院医歯学総合研究科, 講師 (90336347)
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| Project Period (FY) |
2011 – 2012
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| Keywords | HIV / 潜伏感染 / 遺伝子発現 / 宿主因子 / 活性化 |
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| Research Abstract |
Microarray analysis revealed that 15 cellular factor genes were significantly upregulated along with HIV-1 expression in latently infected cells stimulated with TNF-α. Among the factors, Galectin-3 was found to promote HIV-1 expression through NF-κB activation in the cells.
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