2012 Fiscal Year Final Research Report
The development of the side effect prediction of the anticancer agent which assumed intestinal tract immunity an index and the rating system
| Project/Area Number |
23659278
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Applied pharmacology
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
ISEKI Ken 北海道大学, 大学院・薬学研究院, 教授 (40203062)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Natsuko 北海道薬科大学, 薬学部, 講師 (60535293)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | がん化学療法 / 相互作用 / 腸管免疫 / α-ディフェンシン / 食品素材 / 経口抗がん薬 |
|---|
| Research Abstract |
We detected HD-5 and HD-6 mRNA in Caco-2 cells and evaluated the effects of an oral anticancer drugs. HD-5 and HD-6 mRNA levels were decreased by exposure of tegafur. Moreover, the decrease of the HDs mRNA levels were associated with the increase of IL-1 and IL-8 by tegafur. In addition, we clarified antioxidant materials suppressed theexpression of α-defensins induced by FT at the transcriptional level in Caco-2 cells.
|
