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2012 Fiscal Year Final Research Report

Development of targeted therapy of cancer cells with diagnostic imaging through the application of immunoliposomes

Research Project

  • PDF
Project/Area Number 23659299
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Laboratory medicine
Research InstitutionOkayama University

Principal Investigator

MATSUURA Eiji  岡山大学, 大学院・医歯薬学総合研究科, 教授 (20181688)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Kazuko  岡山大学, 大学院・医歯薬学総合研究科, 助教 (20304298)
Project Period (FY) 2011 – 2012
Keywords分子イメージング / Immuno-Theranostics / がん / メソセリン / リポソーム
Research Abstract

The present study was aimed to develop a monoclonal antibody-based probe for PET and drug delivery targeting mesothelin (MSLN) expressing cancer, through the application of immunoliposomes. A humanized monoclonalantibody was developed from a mouse monoclonal antibody against MSLN. We also started to develop its single-chain variable fragment (scFv). In vivo mouse PET imaging with 64Cu-lableld Fab fragment of anti-MSLN antibody showed faster tumor targeting than the case with 64Cu-labeled anti-MSLN IgG. Liposomes conjugated with humanized anti-MSLN antibody and labeled with Cy5.5 were taken into MSLN-expressing cultured cancer cells in an antibody-dependent manner.

  • Research Products

    (6 results)

All 2013 2012 2011 Other

All Presentation (5 results) Remarks (1 results)

  • [Presentation] Lopez. Autoimmunity, oxidative inflammation, and b2-glycoprotein I in early athereogenesis2013

    • Author(s)
      E. Matsuura,L.R. Lopez.
    • Organizer
      Controversies in rheumatology & autoimmunity
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2013-04-06
  • [Presentation] 抗体を用いる標的医療:動脈硬化、がんへの新たな取り組み2012

    • Author(s)
      松浦栄次
    • Organizer
      シンポジウム「橋渡し研究加速ネットワーク構築に向けて」
    • Place of Presentation
      岡山
    • Year and Date
      2012-07-07
  • [Presentation] β2-Glucoprotein I and oxidative inflammation in atherogenesis of autoimmune atherothrombotic diseases.2012

    • Author(s)
      E. Matsuura, L.R. Lopez, Y. Shoenfeld, P.R.J. Ames.
    • Organizer
      8th International congress on autoimmunity
    • Place of Presentation
      Granada Spain
    • Year and Date
      2012-05-12
  • [Presentation] ナノバイオ標的医療の新しい展開-分子イメージングを含めて-2012

    • Author(s)
      松浦栄次
    • Organizer
      橋渡し研究支援推進プログラム」橋渡し研究ネットワーク構築事業シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2012-01-16
  • [Presentation] 分子イメージングを核とするおかやまメディカルイノベーションセンター(OMIC)の設立と将来展望2011

    • Author(s)
      松浦栄次
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      つくば
    • Year and Date
      2011-10-29
  • [Remarks] ホームページ(岡山大学 産学官連携センター「おかやまメディカルイノベーションセンター(OMIC)」

    • URL

      http://www.okayama-u.ac.jp/user/crc/index.htm

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Published: 2014-09-25  

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