Research Project
Grant-in-Aid for Challenging Exploratory Research
We found that capsiate, an ingredient contained in non-pungent capsicum, activates TRPA1. We found that Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner. We found that two isothiocyanates from Wasabia japonica (6-MSITC, 6-MTITC) activate TRPA1. We found that 1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1 upon intensive screening.
All 2012 2011 Other
All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (2 results) Remarks (1 results)
Br. J. Pharmacol
Volume: 165 Pages: 1476-1486
doi:10.1111/j.1476-5381.2011.01634.x.
Pfluger Archiv. Eur. J. Physiol.
Volume: 463 (4) Pages: 549-59
DOI:10.1007/s00424-011-1069-4
Chemical Senses
Volume: 37 Pages: 809-818
DOI:10.1093/chemse/bjs065
Molecular Pain
Volume: 8 Pages: 86
DOI:11.1186/1744-8069-8-86
http://www.nips.ac.jp/cs