2013 Fiscal Year Final Research Report
Role of neurogenesis in mechanism of chronic or late-onset toxicity of environmental chemicals to the central nervous system
| Project/Area Number |
23659326
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene
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| Research Institution | Nagoya University |
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Principal Investigator |
ICHIHARA Gaku 名古屋大学, 医学(系)研究科(研究院), 准教授 (90252238)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMADA Kiyofumi 名古屋大学, 医学部附属病院, 教授 (30303639)
ICHIHARA Sahoko 三重大学, 地域イノベーション研究科, 准教授 (20378326)
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| Project Period (FY) |
2011 – 2013
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| Keywords | バイオマーカー / リスク評価 |
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| Research Abstract |
The present study revealed that exposure to 1-bromopropane, an alternative to ozone-depleting solvents, suppressed neurogenesis in the dentate gyrus of adult rats and noradrenaline, glucocorticoid receptor (GR), brain-derived neurotropic factor (BDNF) are expected to be involved in suppression of the neurogenesis. Change in serotonin level was minimal compared to the decrease in noradrenaline level. Count of proliferative cell in the dentate gyrus, and the level of noradrenaline, GR or BDNF may be used as biomarkers for the toxicity of 1-bromopropane to the central nervous system.
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[Journal Article] Exposure to 1-bromopropane induces microglial changes and oxidative stress in the rat cerebellum2012
Author(s)
Subramanian K, Mohideen SS, Suzumura A, Asai N, Murakumo Y, Takahashi M, Jin S, Zhang L, Huang Z, Ichihara S, Kitoh J, Ichihara G
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Journal Title
Toxicology
Volume: 302(1)
Pages: 18-24
DOI
Peer Reviewed
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[Journal Article] Dose-dependent neurologic abnormalities in workers exposed to 1-bromopropane : authors' response2011
Author(s)
Ichihara G, Wang H, Zhang L, Wakai K, Li W, Ding X, Shibata E, Zhou Z, Wang Q, Li J, Ichihara S, Takeuchi Y
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Journal Title
Journal of Occupational and Environmental Medicine
Volume: 53
Pages: 1095-1098
DOI
Peer Reviewed
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[Journal Article] Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis2011
Author(s)
Nagai H, Okazaki Y, Chew SH, Misawa N, Yamashita Y, Akatsuka S, Ishihara T, Yamashita K, Yoshikawa Y, Yasui H, Jiang L, Ohara H, Takahashi T, Ichihara G, Kostarelos K, Miyata Y, Shinohara H, Toyokuni S
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Journal Title
Proceeding of the National Academy of Sciences of the USA
Volume: 108(49)
Pages: E1330-338
DOI
Peer Reviewed
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[Presentation] Effects of Exposure to 1-Bromopropane on the Level of Thyroid Hormone in Cerebrospinal Fluid of Rats2014
Author(s)
L. Zhang, C. Zong1, N. Koibuchi, S. Ichihara, H. Fujita, J. Chang, J. Huang, H. Naito, M. Kato, G. Ichihara
Organizer
The 53rd Annual Meeting of the Society of Toxicology
Place of Presentation
Phoenix Convention Center, AZ, USA
Year and Date
20140324-27
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[Presentation] Effects of Short- and Long-Term Exposure to 1-Bromopropane on Neurogenesis in Adult Rats2013
Author(s)
L. Zhang, T. Nagai, K. Yamada, D. Ibi, S. Ichihara, K. Subramanian, Z. Huang,S. Sheik Mohideen, H. Naito, G. Ichihara
Place of Presentation
SanAntonio,USA
Year and Date
20130310-14
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