2012 Fiscal Year Final Research Report
Novel molecular-targeting prevention of cancer by sensitizing the effect of sodium butyrate
| Project/Area Number |
23659336
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
SAKAI Toshiyuki 京都府立医科大学, 大学院・医学研究科, 教授 (20186993)
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| Co-Investigator(Kenkyū-buntansha) |
TOMOSUGI Mano (HORINAKA Mano) 京都府立医科大学, 医学研究科, 助教 (80512037)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 癌 / TRAIL / 併用 / 酪酸 |
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| Research Abstract |
The cancer protective efficacy of the dietary fiber is restrictive. One of the reasons is that the expression of TRAIL which works on the antitumor immunity is suppressed by the butyric acid which is the metabolism product of the dietary fiber. It is considered that the cancer protective efficacy of butyric acid could be increased by the combination with a TRAIL inducer, lactic acid bacterium. As a result of the combination of butyrate and lactic acid bacterium in the co-cultivation model of human peripheral blood mononuclear cells and the human cancer cells, a remarkable combination effect was observed. However, the decrease in the expression of TRAIL by butyrate was not fully restored by the combination with lactic acid bacterium unexpectedly. Furthermore, because the combination effect could not be inhibited by the inhibitor of the binding of TRAIL-DR5, it is considered that several factors except TRAIL exist. As a result of this study, it is possible that cancer protective efficacy with the dietary fiber was reinforced by the intake of the lactic acid bacterium.
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[Presentation] 酪酸菌による好中球からの TRAIL 放出機構の解析とその臨床応用への検討.2012
Author(s)
神農雅秀, 堀中真野, 上田崇, 木村泰典, 中村晃和, 本郷文弥, 三神一哉, 高羽夏樹, 河内明宏, 酒井敏行, 三木恒治
Organizer
100回日本泌尿器科学会総会
Place of Presentation
横浜
Year and Date
2012-04-23
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