2012 Fiscal Year Final Research Report
To assess the risk of Attention Deficit/Hyper-Activity Disorder cause byEpigenetic action and gene environment interaction.
| Project/Area Number |
23659341
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Public health/Health science
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
KISHI Reiko 北海道大学, 環境健康科学研究教育センター, 特任教授 (80112449)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
AZUMI Kaoru 北海道大学, 環境健康科学研究教育センター, 特任講師 (90221720)
IKENO Tamiko 北海道大学, 環境健康科学研究教育センター, 特任講師 (80569715)
YOSHIOKA Eiji 旭川医科大学, 医学部, 准教授 (70435957)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SHIRAISHI Hideaki 北海道大学, 大学病院, 助教 (80374411)
SASAKI Seiko 北海道大学, 医学(系)研究科(研究院), 助教 (30448831)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 注意欠損 / 多動性障害(ADHD),環境要因,エピジェネティクス,喫煙,葉酸,環境遺伝相互作用 |
|---|
| Research Abstract |
In this study, for clarification of the effect of smoking on ADHD in 8-year old children, questionnaires containing Conners3 were used in a prospective cohort study. Questionnaires were filled by 1,192 cases with 8 years old. ADHD as outcome were considered as ‘attention- deficit’, ‘hyperactive impulsive’ and ‘comprehensive index’. Smoking of mothers before pregnancy and parents with children at the age of 7 years old, was higher in all of 3 mentioned ADHD categories (p=0.014~0.006). Using Conners3 criteria,8 cases of ADHD were compared to 28 cases as control group. Intelligence test by WISC-IV did not show any significant differences between both of groups. Factors related to ADHD development including environmental chemical exposure, metabolism-related geneticpolymorphism and genetic-environment interaction were summarized in a review article.
|
-
-
[Journal Article] Effects of maternal 5,10-methylenetetrahydrofolate reductase C677T andA1298C polymorphisms and tobacco smoking on infant birth weight in aJapanese population2012
Author(s)
Yila TA, Sasaki S, Miyashita C,Braimoh TS, Kashino I, Kobayashi S, Okada E, Baba T,Yoshioka E, Minakami H, EndoT, Sengoku K, Kishi R.
-
Journal Title
J Epidemiology
Volume: 22(2)
Pages: 91-102
DOI
Peer Reviewed
-
[Journal Article] The Hokkaido Study on Environment and Children's Health in Japan2011
Author(s)
Kishi R, Sasaki S, Yoshioka E, Yuasa M, Sata F,Saijo Y, Kurahashi N, Tamaki J, Endo T, Sengoku, K, Nonomura K, Minakami H. Cohort Profile
-
Journal Title
Int J Epidemiol
Volume: 40(3)
Pages: 611-618
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
[Presentation] Effects of prenatal environmental tobacco smoke exposure on infant birth size2001
Author(s)
Braimoh TS, Sasaki S, Yila TA,Baba T, Miyashita C, Okada E,Kashino I, Ito K, Kobayashi S, Yoshioka E, Kishi R
Organizer
The American Public Health Association (APHA)139th Annual Meeting and Exposition
Place of Presentation
Washington ConventionCenter,USA
Year and Date
20011029-1102
-
