2012 Fiscal Year Final Research Report
Health effect of ionized particle from air purifier on the next generation
| Project/Area Number |
23659361
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Public health/Health science
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
TAKEDA Ken 東京理科大学, 薬学部薬学科, 教授 (80054013)
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| Co-Investigator(Renkei-kenkyūsha) |
UMEZAWA Masakazu 東京理科大学, 総合研究機構, 助教 (60615277)
SHINKAI Yusuke 東京理科大学, 薬学部, PD (80459734)
SUGAMATA Masao , 栃木臨床病理研究所, 所長 (50049863)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 母子保健 |
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| Research Abstract |
The present study showed the results of the potential effect of ionized particle released from some types of air purifier. Our comprehensive research indicated that the potential targets of the particle were the liver and the lymphoid organs. First the present study showed developmental toxicity of the ionized particle: dysregulation of genes related to xenobiotic metabolism and conjugation reaction in the liver, such as Sult1e1. The data indicated the functional characters as well as biomarkers for screening the developmental effect of ionized particle from the air purifier. Accumulation of abnormal ultramicron-sized structure was found in the liver of offspring mouse (next generation) as well asadult mouse (exposed directly to the particle). Metabolome analysis revealed an increase in concentration of metabolites related to purines, urea cycle and amino acids (especially lysine) in the liver of exposure group. Abnormal histopathological features were also found in the lymphoid tissue of mouse of the exposure group. The advantages and disadvantages should be comprehended for safe use of the air purifier.
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[Journal Article] Pre-and postnatal exposure to low-dose diesel exhaust impairs murine spermatogenesis2011
Author(s)
Kubo-Irie, M., Oshio, S., Niwata, Y., Ishihara, A., Sugawara, I.,Takeda, K
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Journal Title
Inhal. Toxicol.
Volume: 23(13)
Pages: 805-813.
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[Journal Article] Evaluation of testicular toxicology of doxorubicin based on microarray analysis of testicular specific gene expression2011
Author(s)
Takahashi,H.,Tainaka,H., Umezawa,M., Takeda,K.,Tanaka,H., Nishimune,Y,. Oshio,S
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Journal Title
J.Toxicol.Sci.
Volume: 36(5)
Pages: 559-567
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