2013 Fiscal Year Final Research Report
Analysis of drinking-derived genetic damage by measuring acetaldehyde adducts
| Project/Area Number |
23659372
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | Suzuka University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 核酸 / 代謝 / 社会医学 / 飲酒 / 遺伝子損傷 |
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| Research Abstract |
To elucidate the influence of acetaldehyde, a metabolite of ethanol taken by drinking, on nucleic acids, the synthesis methods of 1,N2-propanoguanosine monophosphate adduct and 1,N2-propanoguanosine adduct from acetaldehyde were established and the measurement methods of the adducts were developed. The measurement methods were useful to evaluate the genetic damage by acetaldehyde in cultured mammalian cells.
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