2012 Fiscal Year Final Research Report
Preclinical study of stem cell therapy using mesenchymal stem cell derivedfromfresh cadavers.
| Project/Area Number |
23659401
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ARIMURA Yoshiaki 札幌医科大学, 医学部, 講師 (80305218)
FUJIMIYA Mineko 札幌医科大学, 医学部, 教授 (10199359)
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| Project Period (FY) |
2011 – 2012
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| Keywords | fresh cadaver / 骨髄間葉系幹細胞(MSC) / AOM (azoxymethane) |
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| Research Abstract |
The purposes of the study were to elucidate a role of MSC on inflammatory carcinogenesis and to conductpreclinical studies according to GLP. MSC reducedO6MeG adducts and colonic epithelial cells escaped from acute apoptotic response of genotoxic azoxymethane(AOM) finally induced G1 arrest on the cell cycle or apoptosis, which resulted in partially cancel AOM-induced tumor initiation. In the two of nine fresh cadavers, MSCs derived from cadavers could cultivate up to three passages. It is necessary to establish more efficacious isolation and cultivation methods from cadavers’ MSCs.
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[Journal Article] Insulin-like growth factor-I receptor blockade reduces tumor angiogenesis and enhances the effects of bevacizumab for a human gastric cancer cell line2011
Author(s)
Li H, Adachi Y, Yamamoto H, Min Y, Ohashi H, Ii M, Arimura Y, Endo T, Lee CT, Carbone DP, Imai K, Shinomura Y
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Journal Title
MKN45. Cancer
Volume: 117
Pages: 3135-47
Peer Reviewed
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[Journal Article] Myogenic lineage differentiated mesenchymal stem cells enhance recovery from dextran sulfate sodium-induced colitis in the rat2011
Author(s)
Tanaka H, Arimura Y, Yabana T, Goto A, Hosokawa M, Nagaishi K, Yamashita K, Yamamoto H, Sasaki Y, Fujimiya M, Imai K, Shinomura Y
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Journal Title
J Gastroenterol
Volume: 46
Pages: 143-152
Peer Reviewed
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