2012 Fiscal Year Final Research Report
Application of RAGE inhibitor inhalation for COPD
| Project/Area Number |
23659430
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Takuo 金沢学院短期大学, 教授 (40303268)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 閉塞性肺疾患 / RAGE / cAMP / MMP9 |
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| Research Abstract |
(1) We found that ligand-dependent RAGE signal was suppressed by cAMP-dependent signaling pathway, using mouse macrophage culture system.
(2) We showed that cAMP-dependent signal caused activation of MMP9 that accelerated shedding of membrane-bound form RAGE, which resulted in decrease of membrane-bound form RAGE and increase of soluble form RAGE.
(3) The mechanism of the suppression of ligand-dependent RAGE signal by cAMP-dependent signal was supposed that the acceleration of shedding of membrane-bound form RAGE via cAMP-dependent signal resulted in decrease of membrane-bound form RAGE functioning signal transducer and increase of soluble form RAGE functioning decoy receptor.
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