2012 Fiscal Year Final Research Report
Establishment of the technique to convert the immature podocyte to differentiated podocyte with the interdigitated foot process.
| Project/Area Number |
23659442
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 糸球体上皮細胞 / ポドサイト / 足突起 / スリット膜 / カチオンチャンネル / シナプス小胞 |
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| Research Abstract |
In this study we found that TRPM4 a cation channel molecule and neuroligin a synapse protein play a role for podocyte differentiation to form the slit diaphragm. We established the culture technique to form foot process in metanephroi from e-18 rat embryo. It is expected that the transformation of these molecules can enhance the podocyte differentiation. It is convinced that the findings obtained in this study contribute to the establishment the technique to convert the immature podocyte to the differentiated podocyte with the interdigitated foot processes and the slit diaphragm.
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[Journal Article] Irsogladine maleate ameliorates inflammation and fibrosis in mice with chronic colitis induced by dextran sulfate sodium.2012
Author(s)
Yamaguchi H, Suzuki K, Nagata M, Kawase T, Sukumaran V, Thandavarayan RA, Kawauchi Y, Yokoyama J, Tomita M, Kawachi H,Watanabe K, Yoneyama H, Asakura H, Takagi R.
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Journal Title
Med Mol Morphol
Volume: 45
Pages: 140-151
Peer Reviewed
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[Journal Article] Early treatment with everolimus exerts nephroprotective effect in rats with adriamycin-induced nephropathy.2012
Author(s)
Ramadan R, Faour D, Awad H, Khateeb E, Cohen R, Yahia A, Torgovicky R, Cohen R, Lazari D, Kawachi H, Abassi Z.
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Journal Title
Nephrol Dial Transplant.
Volume: 27
Pages: 2231-2241
DOI
Peer Reviewed
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[Journal Article] Early treatment with olmesartan prevents juxtamedullary glomerular podocyte injury and the onset of microalbuminuria in type 2 diabetic rats.2012
Author(s)
Sofue T, Kiyomoto H, Kobori H, Urushihara M, Nishijima Y, Kaifu K, Hara T, Matsumoto S, Ichimura A,Ohsaki H, Hitomi H, Kawachi H, Hayden MR, Whaley-Connell A, Sowers JR, Ito S, Kohno M, Nishiyama A.
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Journal Title
Am J Hypertens.
Volume: 25(5)
Pages: 604-11
DOI
Peer Reviewed
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[Journal Article] Angiotensin II type I receptor blockade suppresses glomerular renin-angiotensin system activation, oxidative stress, and progressive glomerular injury in rat anti-glomerular basement membrane glomerulonephritis.2012
Author(s)
Kinoshita Y, Kondo S, Urushihara M, Suga K, Matsuura S, Takamatsu M, Shimizu M, Nishiyama A, Kawachi H, Kagami S.
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Journal Title
Transl Res.
Volume: 158
Pages: 235-48
DOI
Peer Reviewed
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[Journal Article] Analysis of intestinal fibrosis in chronic colitis in mice induced by dextran sulfate sodium.2011
Author(s)
Suzuki K, Sun X, Nagata M, Kawase T, Yamaguchi H, Sukumaran V, Kawauchi Y, Kawachi H, Nishino T, Watanabe K, Yoneyama H, Asakura H.
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Journal Title
Pathol Int.
Volume: 61
Pages: 228-238
DOI
Peer Reviewed
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[Journal Article] a presynatic adhesion molecule, localizes at the slit diaphragm of the glomerular podocytes in kidneys.2011
Author(s)
Saito A, Miyauchi N, Hashimoto T, Karasawa T, Han GD, Kayaba M, Sumi T, Tomita M, Ikezumi Y, Suzuki K, Koitabashi Y, Shimizu F, Kawachi H. Neurexin-1
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Journal Title
Am J Physiol Regulatory Integrative Comparative Physiology
Volume: 300
Pages: R340-R348
DOI
Peer Reviewed
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[Journal Article] A notable case report of May-Hegglin anomaly with immune complex-related nephropathy: a genetic and histological analysis2011
Author(s)
Ohtsuka Y, Kanaji T, Nishi M, Sakai N, Sato T, Aoki S, Wakayama K, Nakazato S, Hisano S, Sado Y, Kawachi H, Izuhara K, Hamasaki Y.
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Journal Title
Clin Nephrol
Volume: 75
Pages: 255-262
DOI
Peer Reviewed
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[Journal Article] Defective glycosylation of α-dystroglycan contributes to podocyte flattening.2011
Author(s)
Kojima K, Nosaka H, Kishimoto Y, Nishiyama Y, Fukuda S, Shimada M, Kodaka K, Saito F, Matsumura K, Shimizu T, Toda T, Takeda S, Kawachi H, Uchida S.
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Journal Title
Kidney Int
Volume: 79
Pages: 311-316
DOI
Peer Reviewed
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[Journal Article] CD28 superagonist-induced regulatory T cell expansion amelioratesmesangio proliferative glomerulo- nephritis in rats.2011
Author(s)
Miyasato K, Takabatake Y, Kaimori J, Kimura T, Kitamura H, Kawachi H, Li XK, Hunig T, Takahara S, Rakugi H, Isaka Y.
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Journal Title
Clin Exp Nephrol
Volume: 15
Pages: 50-57
DOI
Peer Reviewed
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