2011 Fiscal Year Final Research Report
To establish a rapid diagnostic test in a vCJD patient with Codon 129 Val/Val
| Project/Area Number |
23659451
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011
|
| Keywords | 神経分子病態学 |
|---|
| Research Abstract |
We revealed that bovinized knock-in mice were successfully infected with the agent from knock-in mice with codon 129V/V inoculated with variant Creutzfedlt-jakob disease as well as that from Humanized knock-in mice with codon 129M/M inoculated with variant Creutzfedlt-jakob disease, that from humanized knock-in mice with codon 129M/V inoculated with variant Creutzfedlt-jakob disease, and that from variant Creutzfedlt-jakob disease patients. It provides a new opportunity to re-analyze sporadic Creutzfedlt-jakob disease patients with the 129V/V genotype in countries with bovine spongiform encephalopathy and variant Creutzfedlt-jakob disease, particularly in cases with atypical clinical and neuropathological features.
|
