2012 Fiscal Year Final Research Report
Challenge for the identification of ALS-related viruses
| Project/Area Number |
23659453
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Osaka University |
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Principal Investigator |
KAWAHARA Yukio 大阪大学, 大学院・医学系研究科, 特任准教授 (常勤) (80542563)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 神経分子病態学 / ALS / ウイルス / 神経変性疾患 |
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| Research Abstract |
The aim of this study is to identify RNAs derived from viruses as a causative origin from the autopsied spinal cord of ALS patients. We have successfully established the method to create a cDNA library from RNAs extracted from cultured cells after removal of ribosomal RNAs. We had obtained one autopsied spinal cord of ALS patients. Then, we extracted RNAs from this samples, but it was degraded more severely than expected. We tried to create a cDNA library from this degraded RNAs, but failed in. Since we could establish the method to create cDNA library for deep sequencing, it is promising to analyze whether viral RNAs are involved in or not in ALS samples if we can obtain another samples.
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[Journal Article] A Subset of Circulating MicroRNAs are Predictive for Cardiac Death After Discharge for Acute Myocardial Infarction2012
Author(s)
Matsumoto S, Sakata Y, Nakatani D, Suna S, Mizuno H, Shimizu M, Usami M, Sasaki T, Sato H, Kawahara Y, Hamasaki T, Nanto S, Hori M and Komuro I.
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Journal Title
Biochemical and Biophysical Research Communications
Volume: 427(2)
Pages: 280-284
Peer Reviewed
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