2012 Fiscal Year Final Research Report
Crosstalk between graft-versus-host disease and infection following allogeneic hematopoietic stem cell transplantation
| Project/Area Number |
23659490
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Hokkaido University (2012)
Kyushu University (2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKASHIMA Shuichirou 九州大学, 大学病院, 助教 (70622116)
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| Project Period (FY) |
2011 – 2012
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| Keywords | GVHD / Paneth cell / defensin |
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| Research Abstract |
We discovered that Paneth cells are targeted by GVHD, resulting in marked reduction in the expression of α-defensins, which selectively kill non-commensals, while preserving commensals. Molecular profiling of intestinal microbial communities showed loss of physiological diversity among the microflora and the overwhelming expansion of otherwise rare bacteria, which caused septicemia. These results reveal the novel mechanism responsible for shift in the gut flora from commensals towards the widespread prevalence of pathogens and the previously unrecognized association between GVHD and infection following allogeneic stem cell transplantation.
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Research Products
(29 results)
