2012 Fiscal Year Final Research Report

Comprehensive search of diagnostic biomarker for autism based on mass analysis of peripheral blood and birth cohort study by cord blood

Research Project

Project/Area Number	23659560
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Psychiatric science
Research Institution	Hamamatsu University School of Medicine
Principal Investigator	MORI Norio 浜松医科大学, 医学部, 教授 (00174376)
Co-Investigator(Kenkyū-buntansha)	MATSUZAKI Hideo 福井大学, 子どものこころの発達研究センター, 教授 (00334970) IWATA Keiko 福井大学, 子どものこころの発達研究センター, 特命助教 (30415088) TSUCHIYA Kenji 浜松医科大学, 子どものこころの発達研究センター, 准教授 (20362189)
Co-Investigator(Renkei-kenkyūsha)	TSUJII Masatsugu 中京大学, 現代社会学部, 教授 (20257546)
Project Period (FY)	2011 – 2012
Keywords	自閉症 / 質量分析 / 診断マーカー / 血清
Research Abstract	In this project, we were executing analysis to search specific protein or analyte by mass analysis using serum of individuals with autism. Then, we had a plan to identify the candidate marker molecule for early diagnosis of autism based on the birth cohort by cord blood. In proteomics analysis, we expected to execute differential display by two-dimensional electrophoresis but failed because of the equipment disorder. In metabolome analysis, we identified that free fatty acid and acyl-carnitine were increased in serum of individuals with autism as compared controls, which concluded that lipolysis was progressing in serum of individuals with autism. The birth cohort by cord blood have not yet examined within this term of grant-in-aid.