Evaluation of a screening method based on the"T-cell dysfunction" hypothesis of major depressive disorder.

2012 Fiscal Year Final Research Report

• Project/Area Number: 23659561
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: SUZUKI Katsuaki 浜松医科大学, 医学部, 准教授 (00285040)
• Co-Investigator(Kenkyū-buntansha): SHIMMURA Chie 浜松医科大学, 子どものこころの発達研究センター, 特任研究員 (30529467) ; IWATA Keiko 浜松医科大学, 子どものこころの発達研究センター, 助教 (30415088)
• Project Period (FY): 2011 – 2012
• Keywords: 精神薬理学

Research Abstract

We measured the mRNA levels of apolipoprotein E receptor type 2 (ApoER2) and very low-density lipoprotein receptor (VLDLR) in peripheral blood lymphocytes from 43 patients with major depressive disorder (27 drug-free patients and 16 medicated patients) and 43 age-matched healthy controls using a quantitative real-time RT-PCR method. The correlations between mRNA levels of both receptors and clinical variables in patients were also examined. The expression of ApoER2 mRNA, but not VLDLR, was significantly lower in patients as compared to controls, irrespective of the medication status. There was nostatistically significant correlation between the reduction of ApoER2 mRNA levels and any of the clinical variables measured in patients. Results from this preliminary study suggest that the expression of ApoER2 may serve as a traitmarker for major depressive disorder.

Research Products

• [Journal Article] HBC Study Team. Psychosocial determinants of mistimed and unwanted pr gnancy: the Hamamatsu Birth Cohort (HBC) study (2012)
  • Author(s): Takahashi S, Tsuchiya KJ, Matsumoto K, Suzuki K, Mori N, Takei N
  • Journal Title: Matern Child Health J Volume: 16 Pages: 947-955
• [Journal Article] Vldlr overexpression causes hyperactivity in rats (2012)
  • Author(s): Iwata K, Izummo N, Matsuzaaki H, Manabe T, Ishibashi Y, Ichitani Y, Yamada K, Thanseem I, Anitha A, Vasu MM, Shimmura C, Wakuda T, Kameno Y, Takahashi T, Iwata Y, Suzzuki K, Nakamura K, Mori N
  • Journal Title: Mol Autism Volume: 3 Pages: 11
• [Journal Article] Leukemia inhibitory factor receptor and schizophrenia (2011)
  • Author(s): Kameno Y, Suzuki K, Wakuda T, Takebayashi K, Iwata K, Tsuchiya KJ, Matsuzaki H, Takagai S, Iwata Y, Nakamura K, Mori N
  • Journal Title: Journal of Brain Science Volume: 36 Pages: 32-45
• [Journal Article] Altering the expression balance of hnRNP C1 and C2 changes the expression of myelination-related genes (2011)
  • Author(s): Iwata K, Matsuzaki H, Manabe T, Mori NN
  • Journal Title: Psychiatry Res Volume: 190 Pages: 364-366
• [Presentation] レスモデルにおける局所脳血流・脳糖代謝解析 (2012)
  • Author(s): 亀野 陽亮, 松崎 秀夫, 高橋 健二, 岩田 圭子
  • Organizer: 第39回日本脳科学学会
  • Place of Presentation: 北九州市
  • Year and Date: 2012-10-06